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Titolo:
IMMUNOBIOLOGY OF CYTOTOXIC T-CELL RESISTANT VIRUS VARIANTS - STUDIES ON LYMPHOCYTIC CHORIOMENINGITIS VIRUS (LCMV)
Autore:
MOSKOPHIDIS D; ZINKERNAGEL RM;
Indirizzi:
NATL INST MED RES,DIV MOLEC IMMUNOL,MILL HILL LONDON NW7 1AA ENGLAND UNIV ZURICH,INST EXPT IMMUNOL CH-8091 ZURICH SWITZERLAND
Titolo Testata:
Seminars in virology
fascicolo: 1, volume: 7, anno: 1996,
pagine: 3 - 11
SICI:
1044-5773(1996)7:1<3:IOCTRV>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGENIC VARIATION; MICE; INFECTION; SELECTION; ESCAPE; RECOGNITION; CLEARANCE; MECHANISM; TOLERANCE; IMMUNITY;
Keywords:
CTL ESCAPE VARIANT VIRUS; LCMV; IMMUNOBIOLOGY; VIRAL PERSISTENCE; IMMUNODOMINANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
D. Moskophidis e R.M. Zinkernagel, "IMMUNOBIOLOGY OF CYTOTOXIC T-CELL RESISTANT VIRUS VARIANTS - STUDIES ON LYMPHOCYTIC CHORIOMENINGITIS VIRUS (LCMV)", Seminars in virology, 7(1), 1996, pp. 3-11

Abstract

Replication of the genetically variable lymphocytic choriomeningitis virus (LCMV) gives rise to a pool of variant viruses. Under the selection pressure exerted by a strong but narrow repertoire of antiviral cytotoxic T-cells (CTL) i.e. monoclonal or polyclonal monoepitope, variant viruses emerge that contain point mutations in the nucleotide sequence encoding antigenic CTL epitopes; these variants can be selected inboth infected mice and cell cultures. These mutations permit infectedcells to escape CTL recognition by altering the ability of the mutantpeptides to bind MHC class-I-molecules or by interfering with the ability of T-cell receptors to interact with the mutant peptide/MHC complex. Because viral infections often trigger a polyclonal repertoire of antiviral CTL to multiple epitopes, the likelihood of selection of CTLresistant variants is probably low, but not impossible. Our empiricalobservations suggest that antigenic variations, even if they only occur in a part of the available CTL epitope, may exert significant effects on the subtle biological equilibrium established between virus and host immune system. This can reduce immunological control of the pathogen population, and so permit persistence of viral infection and promote disease progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:45:42