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Titolo:
THE ROLE OF CD11 CD18 INTEGRINS IN THE REVERSE PASSIVE ARTHUS REACTION IN RAT DERMAL TISSUE/
Autore:
ROTE WE; DEMPSEY E; MAKI S; VLASUK GP; MOYLE M;
Indirizzi:
CORVAS INT INC,DEPT MOLEC PHARMACOL,3030 SCI PK RD SAN DIEGO CA 92121 CORVAS INT INC,DEPT BIOL SAN DIEGO CA 92121
Titolo Testata:
Journal of leukocyte biology
fascicolo: 2, volume: 59, anno: 1996,
pagine: 254 - 261
SICI:
0741-5400(1996)59:2<254:TROCCI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENT RECEPTOR TYPE-3; MONOCLONAL-ANTIBODY; LEUKOCYTE ADHESION; POLYMORPHONUCLEAR LEUKOCYTES; INFLAMMATORY REACTIONS; REPERFUSION INJURY; MAC-1 CD11B/CD18; LUNG INJURY; NEUTROPHIL; FIBRINOGEN;
Keywords:
INFLAMMATION; INTEGRINS; MACROPHAGE-1 ANTIGEN; LEUKOCYTE ADHESION RECEPTORS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
W.E. Rote et al., "THE ROLE OF CD11 CD18 INTEGRINS IN THE REVERSE PASSIVE ARTHUS REACTION IN RAT DERMAL TISSUE/", Journal of leukocyte biology, 59(2), 1996, pp. 254-261

Abstract

The CD11/CD18 leukocyte integrins are necessary for tissue localization of neutrophils, an early requisite event in inflammation, We have analyzed the contribution of CD11a/CD18 and CD11b/CD18 to local neutrophil accumulation and tissue injury in the reverse passive Arthus reaction in the rat dermis, Experimental groups comprised animals that received an intravenous infusion of (1) recombinant neutrophil inhibitory factor (NIF), a hookworm-derived antagonist of CD11b/CD18; (2) monoclonal antibody to CD11a/CD18 (TA-3); (3) a combination of these agents; (4) a monoclonal antibody to CD18 (WT.3); or (5) saline. Administration of recombinant NIF or anti-CD11a/CD18 monoclonal antibody alone produced a slight reduction in neutrophil accumulation but did not affect edema formation, In contrast, a combination of these antagonists yielded a significant reduction in neutrophil accumulation and a modest reduction in edema, equivalent to levels observed with either anti-CD18 antibodies or animals that were rendered neutropenic, These results indicate that neutrophil infiltration in rat dermal tissue in the reversepassive Arthus reaction is dependent predominantly on the leukocyte integrins CD11a/CD18 and CD11b/CD18 and that either of these integrins is sufficient for neutrophil trafficking in this inflammatory setting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:51:50