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Titolo:
EFFECT OF ISOFLURANE AND SEVOFLURANE ON THE MAGNITUDE AND TIME-COURSEOF NEUROMUSCULAR BLOCK PRODUCED BY VECURONIUM, PANCURONIUM AND ATRACURIUM
Autore:
VANLINTHOUT LEH; BOOIJ LHDJ; VANEGMOND J; ROBERTSON EN;
Indirizzi:
UNIV NIJMEGEN HOSP,INST ANAESTHESIOL,GEERT GROOTEPLEIN 10,POB 9101 6500 HB NIJMEGEN NETHERLANDS
Titolo Testata:
British Journal of Anaesthesia
fascicolo: 3, volume: 76, anno: 1996,
pagine: 389 - 395
SICI:
0007-0912(1996)76:3<389:EOIASO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE-RESPONSE; ADDUCTOR POLLICIS; NITROUS-OXIDE; ORG NC-45; ANESTHESIA; POTENCY; MAC; TUBOCURARINE; MUSCLES;
Keywords:
ANESTHETICS VOLATILE, ISOFLURANE; ANESTHETICS VOLATILE, SEVOFLURANE; MEASUREMENT TECHNIQUES, ELECTROMYOGRAPHY; MEASUREMENT TECHNIQUES, MECHANOMYOGRAPHY; NEUROMUSCULAR BLOCK, VECURONIUM; NEUROMUSCULAR BLOCK, PANCURONIUM; NEUROMUSCULAR BLOCK, ATRACURIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
L.E.H. Vanlinthout et al., "EFFECT OF ISOFLURANE AND SEVOFLURANE ON THE MAGNITUDE AND TIME-COURSEOF NEUROMUSCULAR BLOCK PRODUCED BY VECURONIUM, PANCURONIUM AND ATRACURIUM", British Journal of Anaesthesia, 76(3), 1996, pp. 389-395

Abstract

We have compared the ability of equipotent concentrations of isoflurane and sevoflurane to enhance the effect of non-depolarizing neuromuscular blocking drugs. Ninety ASA I and II patients of both sexes, aged 18-50 yr, were stratified into three blocker groups (Vee, Pan and Atr), to undergo neuromuscular block with vecuronium (n = 30), pancuronium(n=30) or atracurium (n=30), respectively. Within each group, patients were allocated randomly to one of three anaesthetic subgroups to undergo maintenance of anaesthesia with: (1) alfentanil-nitrous oxide-oxygen (n = 10); (2) alfentanil-nitrous oxide-oxygen-isoflurane (n = 10);or (3) alfentanil-nitrous oxide-oxygen-sevoflurane (n = 10) anaesthesia. During maintenance of anaesthesia, end-tidal concentrations of isoflurane, sevoflurane and nitrous oxide were 0.95, 1.70 and 70%, respectively. Both the evoked integrated electromyogram and mechanomyogram of the adductor pollicis brevis muscle were measured simultaneously. Inthe Vec and Pan groups, a total dose of 40 mu g kg(-1) of vecuronium or pancuronium, respectively, was given, and in the Atr group a total dose of atracurium 100 mu g kg(-1) Each blocker was given in four equal doses and administered cumulatively. We showed that 0.95% isofluraneand 1.70% sevoflurane (corresponding to 0.8 MAC of each inhalation anaesthetic, omitting the MAC contribution of nitrous oxide) augmented and prolonged the neuromuscular block produced by vecuronium, pancuronium and atracurium to a similar degree.

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Documento generato il 30/09/20 alle ore 08:11:07