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Titolo:
CONGENER-SPECIFIC EFFECTS OF PCBS ON CONTRACTIONS OF PREGNANT RAT UTERI
Autore:
TSAI ML; WEBB RC; LOCHCARUSO R;
Indirizzi:
UNIV MICHIGAN,DEPT ENVIRONM & IND HLTH,TOXICOL PROGRAM,1420 WASHINGTON HEIGHTS ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT ENVIRONM & IND HLTH,TOXICOL PROGRAM ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT PHYSIOL ANN ARBOR MI 48109
Titolo Testata:
Reproductive toxicology
fascicolo: 1, volume: 10, anno: 1996,
pagine: 21 - 28
SICI:
0890-6238(1996)10:1<21:CEOPOC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCHLORINATED-BIPHENYLS PCBS; ORGANOCHLORINE COMPOUNDS; PARTURITION; MYOMETRIUM; INVITRO; CALCIUM; LABOR;
Keywords:
UTERUS; UTERINE CONTRACTION; SPONTANEOUS OSCILLATIONS; RATS; POLYCHLORINATED BIPHENYLS; SMOOTH MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Tsai et al., "CONGENER-SPECIFIC EFFECTS OF PCBS ON CONTRACTIONS OF PREGNANT RAT UTERI", Reproductive toxicology, 10(1), 1996, pp. 21-28

Abstract

Both increased and decreased gestation lengths have been reported following exposures to polychlorinated biphenyl (PCB) mixtures and congeners. Because oscillatory uterine contractions are essential for parturition, we hypothesized that the disparate findings on gestation lengthmay be the result of distinct PCB congener-specific actions on oscillatory uterine contractions. This study examined the acute effects of PCB congeners on isometric contractions of isolated pregnant uteri and the structure-activity relationship for individual congeners. After cumulative exposure to individual PCB congeners (0.5 mu M to 150 mu M), oscillatory contractions were: 1) not altered by 2,4,5,2',4',5'-hexachlorobiphenyl, 3,4,5,3',4'-pentachlorobiphenyl, or 3,4,3'4'-tetrachlorobiphenyl; 2) significantly inhibited by 4-hydroxy-2',4',6'-trichlorobiphenyl; and 3) markedly increased by 2,4,6-trichlorobiphenyl and 2,4,2',4'-tetrachlorobiphenyl, when compared to solvent controls. The uteriwere more sensitive to PCB congeners with ortho-substituted light chlorination than those highly chlorinated, or those interacting with theAh-receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:40:58