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Titolo:
DOPAMINE D-2 AND SEROTONIN S-2 RECEPTORS IN SUSCEPTIBILITY TO METHAMPHETAMINE PSYCHOSIS DETECTED BY POSITRON EMISSION TOMOGRAPHY
Autore:
IYO M; NISHIO M; ITOH T; FUKUDA H; SUZUKI K; YAMASAKI T; FUKUI S; TATENO Y;
Indirizzi:
NATL INST MENTAL HLTH,NATL CTR NEUROL & PSYCHIAT ICHIKAWA CHIBA 272 JAPAN NATL MENTAL HOSP SHIMOHUSA,MIDORI KU CHIBA CHIBA JAPAN NIPPON MED COLL,DEPT BASIC SCI,BUNKYO KU TOKYO TOKYO JAPAN NATL INST RADIOL SCI,DIV CLIN RES,INAGE KU CHIBA CHIBA JAPAN
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 4, volume: 50, anno: 1993,
pagine: 217 - 231
SICI:
0925-4927(1993)50:4<217:DDASSR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVING HUMAN-BRAIN; BINDING-SITES; AMPHETAMINE PSYCHOSIS; INVIVO; SCHIZOPHRENIA; STATE; PET; EQUILIBRIUM; DENSITY; MODELS;
Keywords:
STRIATUM; FRONTAL CORTEX; C-11 N-METHYLSPIPERONE; RECEPTOR BINDING; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Iyo et al., "DOPAMINE D-2 AND SEROTONIN S-2 RECEPTORS IN SUSCEPTIBILITY TO METHAMPHETAMINE PSYCHOSIS DETECTED BY POSITRON EMISSION TOMOGRAPHY", PSYCHIATRY RESEARCH-NEUROIMAGING, 50(4), 1993, pp. 217-231

Abstract

Positron emission tomography (PET) was used to assess the role of dopamine D-2 receptors in the striatum and serotonin S-2 receptors in thefrontal cortex in the susceptibility to methamphetamine-induced psychosis. Subjects were six men who had previously experienced methamphetamine psychosis (methamphetamine subjects) and 10 age- and sex-matched control subjects. The radiotracer used was C-11-N-methylspiperone. Although binding availability, assessed by dynamic analysis, in the two regions did not differ between the two groups, the ratio of binding availability in the striatum to that in the frontal cortex significantly decreased in the methamphetamine subjects as compared with the controlsubjects. These findings suggest that an imbalance in the activity ofthese two receptors may be related to the susceptibility to methamphetamine psychosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:32:39