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Titolo:
INHIBITORY EFFECTS OF BOTULINUM TOXIN ON 5-HT(1C) RECEPTOR-INDUCED CL- CURRENT IN XENOPUS-OOCYTES
Autore:
TOHDA M; TAKASU T; NAKAMURA J; MORII N; NARUMIYA S; NOMURA Y;
Indirizzi:
HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KITA KU SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KITA KU SAPPORO HOKKAIDO 060 JAPAN KYOTO UNIV,FAC MED,DEPT PHARMACOL,SAKYO KU KYOTO KYOTO 606 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST ORIENTAL MED WAKAN YAKU,DEPT NEUROSCI TOYAMA TOYAMA 93001 JAPAN
Titolo Testata:
European journal of pharmacology. Molecular pharmacology section
fascicolo: 1, volume: 266, anno: 1994,
pagine: 19 - 24
SICI:
0922-4106(1994)266:1<19:IEOBTO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTP-BINDING-PROTEIN; RHO-GENE-PRODUCT; ADP-RIBOSYLTRANSFERASE; PHOSPHOLIPASE-C; ALPHA-SUBUNIT; PURIFICATION; CELLS; IDENTIFICATION; RIBOSYLATION; ACTIVATION;
Keywords:
G PROTEIN (LOW MOLECULAR WEIGHT); POLYPHOSPHOINOSITIDE TURNOVER; BOTULINUM TOXIN; ADP-RIBOSYLATION, 5-HT (5-HYDROXYTRYPTAMINE, SEROTONIN); XENOPUS OOCYTE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M. Tohda et al., "INHIBITORY EFFECTS OF BOTULINUM TOXIN ON 5-HT(1C) RECEPTOR-INDUCED CL- CURRENT IN XENOPUS-OOCYTES", European journal of pharmacology. Molecular pharmacology section, 266(1), 1994, pp. 19-24

Abstract

Several low molecular weight G proteins have been identified, but their functional roles remain unclear. To clarify the involvement of low molecular weight G protein in receptor-stimulated turnover of polyphosphoinositide (PI) turnover, influences of botulinum toxins on serotonin (5-HT)-stimulated Cl- current mediated by PI turnover were investigated using Xenopus oocytes injected with rat brain mRNA. Treatment withbotulinum toxin C, D or purified ADP-ribosyltransferase of botulinum toxin (botulinum toxin C3 enzyme) inhibited the 5-HT-induced Cl- current in oocytes, and ADP-ribosylated 23 kDa proteins. Both botulinum toxin C3 enzyme-induced inhibition of the current and ADP-ribosylation were suppressed by pretreatment with antibotulinum toxin C3 enzyme antibody. Botulinum toxin D treatment of oocytes was ineffective in the response of Cl- current induced by injection of 50 pmol inositol 1,4,5-trisphosphate and 50 pmoI Ca2+. It is suggested that low molecular weight G proteins ADP-ribosylated by botulinum toxin C3 enzyme are involvedin phospholipase C activation in Xenopus oocytes.

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Documento generato il 05/07/20 alle ore 05:51:04