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Titolo:
HIGH-DOSE FENTANYL DOES NOT SUPPRESS INTERLEUKIN-1-BETA-INDUCED INCREASES IN PLASMA ACTH AND CORTICOSTERONE IN RATS
Autore:
NUMAI T; INABA H; MIZUGUCHI T;
Indirizzi:
CHIBA UNIV,SCH MED,DEPT ANESTHESIOL CHIBA 280 JAPAN AKITA UNIV,SCH MED,DEPT EMERGENCY MED AKITA 010 JAPAN
Titolo Testata:
Acta anaesthesiologica Scandinavica
fascicolo: 2, volume: 40, anno: 1996,
pagine: 143 - 150
SICI:
0001-5172(1996)40:2<143:HFDNSI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CARDIOPULMONARY BYPASS; ENDOTOXIN; SURGERY; INDUCTION; SECRETION; RELEASE;
Keywords:
ACTH; ANESTHESIA; CORTICOSTERONE; FENTANYL; IMMUNONEUROENDOCRINE SYSTEM; INTERLEUKIN-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
T. Numai et al., "HIGH-DOSE FENTANYL DOES NOT SUPPRESS INTERLEUKIN-1-BETA-INDUCED INCREASES IN PLASMA ACTH AND CORTICOSTERONE IN RATS", Acta anaesthesiologica Scandinavica, 40(2), 1996, pp. 143-150

Abstract

Background. High-dose fentanyl anesthesia is reported to attenuate the metabolic and endocrinal responses to surgery. Interleukin-1 (IL-1) is one of the key mediators in the immunoneuroendocrine system, and may be involved in the stress responses to surgery. We studied whether high-dose fentanyl may influence the IL-lp-induced alterations in plasma ACTH and corticosterone in rats. Methods. Plasma ACTH, corticosterone, blood pressure, heart rate and acid-base status were determined in either awake or fentanyl-anesthetized animals immediately before and after either phosphate buffered saline or IL-1 beta administration. Fentanyl anesthesia was induced by bolus intravenous injections of fentanyl at 50 mu g/kg and pancuronium bromide at 0.2 mg/kg, and maintained by continuous administrations of fentanyl at 100 or 200 mu g.kg(-1).h(-1) and pancuronium bromide at 0.4 mu g.kg(-1).h(-1). Results. In awake rats, IL-1 beta at incremental doses of 0.25, 0.5 and 1 mu g/kg increased plasma ACTH in a dose-dependent manner, but heat-inactivated IL-1 beta at 4 mu g/kg did not influence plasma ACTH. A noxious stimulus with tail clamping for 30 min did not significantly alter plasma ACTH in fentanyl-anesthetized rats. Fentanyl reduced the basal plasma corticosterone, but it did not modulate the increases in plasma ACTH and corticosterone after the administration of IL-1 beta at 1 mu g/kg. Fentanyl moderately increased the basal blood pressure and heart rate, but it moderately attenuated the IL-1 beta-induced elevations of blood pressure and heart rate. IL-1 beta moderately decreased Pco(2) in awake animals. Conclusions. Fentanyl anesthesia, which is able to suppress the endocrine responses to noxious stimuli, does not attenuate the IL-1 beta-mediated activation of the pituitary-adrenal axis in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:52:19