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Titolo:
MEASUREMENT OF LIVER BLOOD-FLOW USING O-15 LABELED WATER AND DYNAMIC POSITRON EMISSION TOMOGRAPHY - LIMITATIONS OF MODEL DESCRIPTION
Autore:
ZIEGLER SI; HABERKORN U; BYRNE H; TONG C; SCHOSSER R; KRIETER H; KAJA S; RICHOLT JA; LAMMERTSMA AA; PRICE P;
Indirizzi:
TECH UNIV MUNICH,NUKL MED KLIN RECHTS DER ISAR,ISMANINGER STR 22 D-81675 MUNICH GERMANY DEUTSCH KREBSFORSCHUNGSZENTRUM,FORSCH SCHWERPUNKT RADIOL DIAGNOST & THERAPIE D-69120 HEIDELBERG GERMANY TECH UNIV MUNICH,ABT EXPT CHIRURG D-81675 MUNICH GERMANY HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT LONDON W12 0HS ENGLAND
Titolo Testata:
European journal of nuclear medicine
fascicolo: 2, volume: 23, anno: 1996,
pagine: 169 - 177
SICI:
0340-6997(1996)23:2<169:MOLBUO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS (H2O)-O-15; INTEGRAL METHODS; QUANTIFICATION; ARTERIAL; INVIVO; ERROR;
Keywords:
POSITRON EMISSION TOMOGRAPHY; LIVER PERFUSION; MODELING; O-15 LABELED WATER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S.I. Ziegler et al., "MEASUREMENT OF LIVER BLOOD-FLOW USING O-15 LABELED WATER AND DYNAMIC POSITRON EMISSION TOMOGRAPHY - LIMITATIONS OF MODEL DESCRIPTION", European journal of nuclear medicine, 23(2), 1996, pp. 169-177

Abstract

To date no satisfactory method has been available for the quantitative in vivo measurement of the complex hepatic blood flow, In this studytwo modelling approaches are proposed for the analysis of liver bloodflow using positron emission tomography (PET), Five experiments were performed on three foxhounds. The anaesthetised dogs were each given an intravenous bolus injection of oxygen-15 labelled water, and their livers were then scanned using PET, Radioactivity in the blood from theaorta and portal vein was measured directly and simultaneously using closed external circuits. Time-activity curves were constructed from sequential PET data. Data analysis was performed by assuming that waterbehaves as a freely diffusible tracer and adapting the standard one-compartment blood flow model to describe the dual blood supply of the liver. Two particular modelling approaches were investigated: the dual-input model used both directly measured input functions (i.e. using the hepatic artery and the portal vein input, determined from the radioactivity detected in the aorta and portal vein respectively) whereas the single-input model used only the measured arterial curve and predicted the corresponding portal input function. Hepatic arterial flow, portal flow and blood volume were fitted from the PET data in several regions of the liver. The resulting estimates were then compared with reference blood flow measurements, obtained using a standard microsphere technique. The microspheres were injected in a separate experiment on the same dogs immediately prior to PET scanning, Whilst neither the single- nor the dual-input models accurately reproduced the arterial reference flow values, the flow values from the single-input model were closer to the microsphere flow values. The proposed single-input model would be a good approximation for liver blood flow measurements in man. The observed discrepancies between the PET and microsphere flow values may be due to the inherent temporal and spatial heterogeneity of liver blood flow. The results presented suggest that adaptation of the standard one-compartment blood flow model to describe the dual blood supply of the liver is limited and other flow tracers have to be considered for quantitative PET measurements in the liver.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:45:52