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Titolo:
ASSESSING NEURORECEPTOR OCCUPANCY BY CONTINUOUS-INFUSION OF C-11 LABELED RADIOLIGANDS
Autore:
KAO PF; KIM S; WAGNER HN; LEVER JR; RAVERT HT; DANNALS RF;
Indirizzi:
JOHNS HOPKINS MED INST,DIV NUCL MED,615 N WOLFE ST BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DIV NUCL MED BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DIV RADIAT HLTH SCI BALTIMORE MD 21205 CHANG GUNG MEM HOSP,DEPT NUCL MED TAIPEI 10591 TAIWAN
Titolo Testata:
European journal of nuclear medicine
fascicolo: 2, volume: 23, anno: 1996,
pagine: 141 - 144
SICI:
0340-6997(1996)23:2<141:ANOBCO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; OPIATE RECEPTORS;
Keywords:
EQUILIBRIUM STATE; CONTINUOUS INFUSION; C-11 RADIOLIGANDS; DUAL-PROBE DETECTOR SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
P.F. Kao et al., "ASSESSING NEURORECEPTOR OCCUPANCY BY CONTINUOUS-INFUSION OF C-11 LABELED RADIOLIGANDS", European journal of nuclear medicine, 23(2), 1996, pp. 141-144

Abstract

In carbon-11 labeled radiotracer studies of neuroreceptors in the brain, a state of practical equilibrium, monitored with a simple dual-probe detector system, was achieved by injection of a bolus of tracer followed by a continuous infusion of the tracer, After investigating several different bolus-to-infusion activity ratios, we observed that a practical equilibrium state could be achieved with a slope of 0.02+/-0.001 cpsxkg/mu Ci/min for [C-11]carfentanil studies in normal human beings, The usefulness of this approach to assess neuroreceptor occupancy was demonstrated in two cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:47:38