Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BIOCHEMICAL MARKERS OF ALCOHOL-ABUSE
Autore:
SHARPE PC; MCBRIDE R; ARCHBOLD GPR;
Indirizzi:
BELFAST CITY HOSP,DEPT CLIN BIOCHEM,LISBURN RD BELFAST BT9 7AB ANTRIMNORTH IRELAND BELFAST CITY HOSP,DEPT CLIN CHEM BELFAST BT9 7AD ANTRIM NORTH IRELAND
Titolo Testata:
Quarterly Journal of Medicine
fascicolo: 2, volume: 89, anno: 1996,
pagine: 137 - 144
SICI:
1460-2725(1996)89:2<137:BMOA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBOHYDRATE-DEFICIENT TRANSFERRIN; MITOCHONDRIAL ASPARTATE-AMINOTRANSFERASE; ANION-EXCHANGE CHROMATOGRAPHY; GLUTATHIONE S-TRANSFERASE; CAGE QUESTIONNAIRE; HEAVY DRINKING; SERUM; CONSUMPTION; DAMAGE; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P.C. Sharpe et al., "BIOCHEMICAL MARKERS OF ALCOHOL-ABUSE", Quarterly Journal of Medicine, 89(2), 1996, pp. 137-144

Abstract

Excessive alcohol consumption is a major health problem in the UK leading to both serious morbidity and mortality. This study compared newer potential biochemical markers of excessive alcohol consumption [carbohydrate-deficient transferrin (CDT), mitochondrial AST (mAST) and alpha glutathiones-transferase (alpha-GST)] with conventional markers (AST, ALT, GGT, MCV). Patients (n=85) were enrolled in the study and subdivided into several groups on the basis of alcohol consumption. Patients with non-alcoholic liver disease (NALD) (n=40) were also enrolled. All the markers, with the exception of the ratio mAST/total AST were significantly higher in heavy drinkers/alcoholics compare to teetotallers/social drinkers (p<0.05). mAST and AST/ALT ratio were significantlyhigher in alcoholics compared to NALD (p<0.01), whereas ALT was higher in the NALD group (p<0.05). Multivariate discriminant function analysis (Wilks method) demonstrated that the logarithmic functions of AST/ALT ratio and mAST could correctly classify 87.9% of cases into eitherthe alcoholic or NALD groups. ROC plot analysis showed that AST, mASTand CCT were the best markers at distinguishing heavy consumption of alcohol from lesser levels and that AST/ALT ratio and mAST were the best in distinguishing alcoholics from NALD. In conclusion, none of the newer biochemical markers, with the exception of mAST, offers any major advantage over the conventional markers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:16:41