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Titolo:
PREGNANCY OUTCOME IN WOMEN WITH LOW MIDTRIMESTER MATERNAL SERUM UNCONJUGATED ESTRIOL
Autore:
SANTOLAYAFORGAS J; JESSUP J; BURD LI; PRINS GS; BURTON BK;
Indirizzi:
MICHAEL REESE HOSP & MED CTR,CTR MED & REPROD GENET,2929 S ELLIS AVE CHICAGO IL 60616 MICHAEL REESE HOSP & MED CTR,REPROD BIOL LAB CHICAGO IL 60616 UNIV ILLINOIS,COLL MED,DEPT OBSTET & GYNECOL CHICAGO IL 00000 UNIV ILLINOIS,COLL MED,DEPT PEDIAT CHICAGO IL 00000
Titolo Testata:
Journal of reproductive medicine
fascicolo: 2, volume: 41, anno: 1996,
pagine: 87 - 90
SICI:
0024-7758(1996)41:2<87:POIWWL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-FETOPROTEIN; DOWNS-SYNDROME; FETAL GROWTH; HCG;
Keywords:
ESTRIOL; PREGNANCY OUTCOME; PREGNANCY TRIMESTER; 2ND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J. Santolayaforgas et al., "PREGNANCY OUTCOME IN WOMEN WITH LOW MIDTRIMESTER MATERNAL SERUM UNCONJUGATED ESTRIOL", Journal of reproductive medicine, 41(2), 1996, pp. 87-90

Abstract

OBJECTIVE: To determine if unexplained low second-trimester maternal serum unconjugated estriol (MSuE3) is a useful predictor of complications of pregnancy.STUDY DESIGN: Between February 1, 1990, and January 3, 1993, 10,492 patients underwent prenatal screening using second-trimester maternal serum alpha-fetoprotein (MSAFP), maternal serum human chorionic gonadotropin (MShCG) and MSuE3. One hundred ninety-five patients with complete obstetric history/delivery records and with <0.4 multiples of the median (MoM) second-trimester MSuE3 values were matched with 261 controls with complete obstetric history/delivery records andnormal second-trimester MSAFP, MSuE3 and MShCG. RESULTS: The relativerisk of pregnancy loss, as compared to that in controls, was 3.7 (1.4-9.1 confidence interval [CI], P<.0001) in patients with 0.2-0.4 MoM MSuE3 and 19.3 (6.1-60.5 CI, P<.0001) in patients with <0.2 MoM MSuE3. After exclusion of patients with low and high MSAFP and MShCG, the relative risk of pregnancy loss for the remaining patients with low MSuE3teas 3.3 (1.3-8.5 CI, P<.008). CONCLUSION: The data suggest that patients with unexplained low second-trimester MSuE3 have an increased risk of pregnancy loss that may not be associated with a high or low MSAFP, MShCG or higher incidence of pregnancy-induced hypertension, gestational diabetes, premature rupture of membranes or premature onset of labor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:54:59