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Titolo:
LOW MG2+ INDUCED EPILEPTIFORM ACTIVITY IN THE SUBICULUM BEFORE AND AFTER DISCONNECTION FROM RAT HIPPOCAMPAL AND ENTORHINAL CORTEX SLICES
Autore:
BEHR J; HEINEMANN U;
Indirizzi:
HUMBOLDT UNIV BERLIN,DEPT NEUROPHYSIOL,INST PHYSIOL,TUCHOLSKYSTR 2 D-10117 BERLIN GERMANY
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 205, anno: 1996,
pagine: 25 - 28
SICI:
0304-3940(1996)205:1<25:LMIEAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIZATION; PROJECTIONS; PATHWAYS; COMPLEX; REGION;
Keywords:
SUBICULUM; SEIZURE LIKE EVENTS; LATE RECURRENT DISCHARGES; LOW MAGNESIUM; MEMBRANE POTENTIAL CHANGES; FIELD POTENTIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J. Behr e U. Heinemann, "LOW MG2+ INDUCED EPILEPTIFORM ACTIVITY IN THE SUBICULUM BEFORE AND AFTER DISCONNECTION FROM RAT HIPPOCAMPAL AND ENTORHINAL CORTEX SLICES", Neuroscience letters, 205(1), 1996, pp. 25-28

Abstract

The subiculum is an area within the hippocampal complex which participates strongly in ictaform activity generated in the entorhinal cortex(EC). To study the properties of epileptiform activity with intra- and extracellular recording techniques in the subiculum, combined slicescontaining the EC, subiculum and hippocampus were prepared with and without surgical disconnection of the subiculum from the EC and area CA1. For induction of epileptiform activity extracellular magnesium was lowered. After acute disconnection of the subiculum from the cornu ammonis and the EC, seizure: like events similar to those in the more intact preparation did develop. These were characterized by slow negativefield potential shifts and, in intracellular recordings by sustained depolarization shifts lasting for 10-43 s. This activity could developinto late recurrent discharges of 1-2 s. These data indicate that thesubiculum may be an important zone for epileptogenesis in temporal lobe epilepsy.

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Documento generato il 27/01/20 alle ore 07:28:29