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Titolo:
A CASE OF LINEAR IGA BULLOUS DERMATOSIS WITH IGA ANTI-TYPE-VII COLLAGEN AUTOANTIBODIES
Autore:
HASHIMOTO T; ISHIKO A; SHIMIZU H; TANAKA T; DODD HJ; BHOGAL BS; BLACK MM; NISHIKAWA T;
Indirizzi:
KEIO UNIV,SCH MED,DEPT DERMATOL,SHINJUKU KU,35 SHINANOMACHI TOKYO 160JAPAN KYOTO UNIV,FAC MED,DEPT DERMATOL KYOTO JAPAN OLDCHURCH HOSP,DEPT DERMATOL ROMFORD RM7 0BE ESSEX ENGLAND ST JOHNS INST DERMATOL,DEPT DERMATOPATHOL LONDON ENGLAND
Titolo Testata:
British journal of dermatology
fascicolo: 2, volume: 134, anno: 1996,
pagine: 336 - 339
SICI:
0007-0963(1996)134:2<336:ACOLIB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASEMENT-MEMBRANE; INDIRECT IMMUNOFLUORESCENCE; LAMINA DENSA; IDENTIFICATION; SKIN; CHILDHOOD; ACQUISITA; DISEASE; ADULTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
T. Hashimoto et al., "A CASE OF LINEAR IGA BULLOUS DERMATOSIS WITH IGA ANTI-TYPE-VII COLLAGEN AUTOANTIBODIES", British journal of dermatology, 134(2), 1996, pp. 336-339

Abstract

In this study we present a patient with the sublamina densa type of linear IgA bullous dermatosis (LABD), with IgA autoantibodies reactive with the 290-kDa type VII collagen (the epidermolysis bullosa acquisita (EBA) antigen) and with immunoblotting of normal human dermal extracts. The clinical and histological features of the present case were compatible with those of LABD but quite different from those of EBA. Although EBA sera reacted with the bacterial fusion protein of the N-terminal globular (NC1) domain of type VII collagen, this patient's serum did not show reactivity. Furthermore, ultrastructural localization of target epitopes on the anchoring fibrils in this patient was considerably different from EBA. These results indicate that, whereas EBA antibodies react with the NC1 domain of type VII collagen, the epitope in this case is different from that of EBA (and is most likely on the central triple helical domain). This difference may be responsible for theclinical presentation in this patient being distinct from that of EBA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 12:17:32