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Titolo:
PROGNOSTIC FACTORS FOR THE SURVIVAL IN IN FILTRATING BLADDER UROTHELIAL TUMOR - RETROSPECTIVE STUDY OF 158 PATIENTS TREATED BY RADICAL CYSTECTOMY
Autore:
THIEBLEMONT C; FENDLER JP; TRILLETLENOIR V; PETRIS C; CHAUVIN F; BRUNATMENTIGNY M; DEVAUX Y; DEVONEC M; GERARD JP; PERRIN P;
Indirizzi:
CTR HOSP LYON SUD,SERV RADIOTHERAPIE ONCOL,165 CHEM GRAND REVOYET F-69495 PIERRE BENITE FRANCE CTR HOSP LYON SUD,SERV RADIOTHERAPIE ONCOL F-69495 PIERRE BENITE FRANCE HOP ANTIQUAILLE,UROL SERV F-69321 LYON 05 FRANCE CTR LEON BERARD,UNITE BIOSTAT & EVALUAT THERAPEUT F-69373 LYON FRANCE CTR LEON BERARD,SERV ONCOL PEDIAT F-69373 LYON 08 FRANCE
Titolo Testata:
Bulletin du cancer
fascicolo: 2, volume: 83, anno: 1996,
pagine: 139 - 146
SICI:
0007-4551(1996)83:2<139:PFFTSI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
FRE
Soggetto:
TRANSITIONAL-CELL-CARCINOMA; ADJUVANT CHEMOTHERAPY; M-VAC; CANCER; METHOTREXATE; CISPLATIN; VINBLASTINE; DOXORUBICIN; EXPRESSION; MANAGEMENT;
Keywords:
TRANSITIONAL CELL CARCINOMA; INFILTRATING BLADDER CANCER; SURVIVAL; CHEMOTHERAPY; RADIOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C. Thieblemont et al., "PROGNOSTIC FACTORS FOR THE SURVIVAL IN IN FILTRATING BLADDER UROTHELIAL TUMOR - RETROSPECTIVE STUDY OF 158 PATIENTS TREATED BY RADICAL CYSTECTOMY", Bulletin du cancer, 83(2), 1996, pp. 139-146

Abstract

The clinical files of 158 patients who were treated by radical cystectomy for infiltrating bladder carcinoma were retrospectively reviewed to define prognostic factors. Patients and methods. - All patients hada radical cystectomy with bilateral pelvic lymph node dissection for an infiltrating operable bladder urothelial tumor. Each tumor was classified according the pTNM staging system and were analysed for the presence of vascular invasion, carcinoma in situ and tumor grade. Twenty-three patients (14.5%) had an irradiation. Sixty-seven patients (42%) received chemotherapy (neoadjuvant in 31, adjuvant in 30, both in 6). Results. - The median overall survival of the whole group was 19 months. The 5 years disease free survival (DFS) and overall survival (OS) were 44% and 31%, respectively. In the univariate analysis, the factorswith significant prognostic value were: pT stage and the tumor size for OS, age and lymph node involvment for DFS, presence of carcinoma insitu (CIS) and tumor size for local recurrence free survival (LRFS) and sex and lymph node involvment for metastatic free survival (MFS). The following variables attained significant prognostic value in the multivariate analysis: pT stage and an interaction between lymph node involvment and vascular invasion for OS, pT stage and presence of CIS for LRFS, pT stage for MFS. Conclusion. - The pT stage, lymph node involvment and vascular invasion are the most important prognostic factors of survival in infiltrating bladder cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:29:46