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Titolo:
MITE-SPECIFIC INDUCTION OF INTERLEUKIN-2 RECEPTOR ON T-LYMPHOCYTES FROM CHILDREN WITH MITE-SENSITIVE ASTHMA - MODIFIED IMMUNE-RESPONSE WITHIMMUNOTHERAPY
Autore:
BONNO M; FUJISAWA T; IGUCHI K; UCHIDA Y; KAMIYA H; KOMADA Y; SAKURAI M;
Indirizzi:
MIE NATL HOSP,DEPT PEDIAT,375 OSATO KUBOTA TSU MIE 51401 JAPAN MIE NATL HOSP,DEPT PEDIAT TSU MIE 51401 JAPAN MIE UNIV,SCH MED,DEPT PEDIAT TSU MIE 51401 JAPAN
Titolo Testata:
Journal of allergy and clinical immunology
fascicolo: 2, volume: 97, anno: 1996,
pagine: 680 - 688
SICI:
0091-6749(1996)97:2<680:MIOIRO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; HOUSE DUST; DERMATOPHAGOIDES-PTERONYSSINUS; BRONCHIAL BIOPSIES; GRASS-POLLEN; ALLERGEN; CELLS; RESPONSIVENESS; HYPOSENSITIZATION; EOSINOPHILS;
Keywords:
IL-2 RECEPTOR; CD25; MIK-BETA-1; ASTHMA; IMMUNOTHERAPY; CHILDREN; DERMATOPHAGOIDES FARINAE; CD8(+) T LYMPHOCYTE; IGG(4);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Bonno et al., "MITE-SPECIFIC INDUCTION OF INTERLEUKIN-2 RECEPTOR ON T-LYMPHOCYTES FROM CHILDREN WITH MITE-SENSITIVE ASTHMA - MODIFIED IMMUNE-RESPONSE WITHIMMUNOTHERAPY", Journal of allergy and clinical immunology, 97(2), 1996, pp. 680-688

Abstract

Background: The efficacy of immunotherapy is still controversial. To elucidate the mechanisms of immunotherapy, we studied mite-specific induction of IL-2 receptor (IL-2R) expression on T lymphocytes from children with mite-sensitive asthma. Methods: Peripheral blood mononuclearcells were obtained from 28 children with mite-sensitive asthma: 13 had never received house dust immunotherapy (nonimmunotherapy group), 15 had been receiving house dust immunotherapy at the time of the study(immunotherapy group). After a 6-day culture with or without Dermatophagoides farinae (Df) antigen, the expression of IL-2Rp55 (CD25) and p75 on CD4(+) or CD8(+) T lymphocytes was measured by flow cytometry. Results: The nonimmunotherapy group showed significant Df-specific CD25induction on CD4(+) T lymphocytes (Delta CD4(+) CD25(+)) but little induction on CD8(+) T lymphocytes (Delta CD8(+) CD25(+)). Delta CD4(+) CD25(+) was correlated with the severity of the disease. In the immunotherapy group Delta CD8(+) CD25(+) was significantly higher than in the nonimmunotherapy group or in normal subjects and correlated with Df-specific IgG(4) and cumulative doses of house dust extract, whereas Delta CD4(+) CD25(+) was similar in the nonimmunotherapy and the immunotherapy groups. IL-2Rp75 was not induced either on CD4(+) or CD8(+) T lymphocytes. Conclusions: Our data suggest that house dust immunotherapy may have induced Df-specific CD8(+) T lymphocytes in patients with mite-sensitive asthma and that the efficacy of immunotherapy may be attributed to the generation of Df-specific CD8(+) T lymphocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:41:09