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Titolo:
EXPOSURE OF ASTROCYTES TO HYPOXIA REOXYGENATION ENHANCES EXPRESSION OF GLUCOSE-REGULATED PROTEIN-78 FACILITATING ASTROCYTE RELEASE OF THE NEUROPROTECTIVE CYTOKINE INTERLEUKIN-6
Autore:
HORI O; MATSUMOTO M; KUWABARA K; MAEDA Y; UEDA H; OHTSUKI T; KINOSHITA T; OGAWA S; STERN DM; KAMADA T;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT MED 1,2-2 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT MED 1 SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT NEUROL SUITA OSAKA 565 JAPAN OSAKA UNIV,MICROBIAL DIS RES INST,DEPT IMMUNOREGULAT SUITA OSAKA 565 JAPAN COLUMBIA UNIV COLL PHYS & SURG,DEPT PHYSIOL & CELLULAR BIOPHYS NEW YORK NY 10032
Titolo Testata:
Journal of neurochemistry
fascicolo: 3, volume: 66, anno: 1996,
pagine: 973 - 979
SICI:
0022-3042(1996)66:3<973:EOATHR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCTION; BRAIN; DISSOCIATION; ENDOTHELIUM; SECRETION; TOLERANCE; STRESS; CELLS; GRP78; ATP;
Keywords:
STRESS PROTEINS; OXYGEN-REGULATED PROTEINS; CYTOKINE; INTERLEUKIN 6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
O. Hori et al., "EXPOSURE OF ASTROCYTES TO HYPOXIA REOXYGENATION ENHANCES EXPRESSION OF GLUCOSE-REGULATED PROTEIN-78 FACILITATING ASTROCYTE RELEASE OF THE NEUROPROTECTIVE CYTOKINE INTERLEUKIN-6", Journal of neurochemistry, 66(3), 1996, pp. 973-979

Abstract

Astrocytes exposed to hypoxia(H) or hypoxia/reoxygenation (H/R) maintain cell viability and display changes in protein biosynthesis, Sodiumdodecyl sulfate-polyacrylamide gel electrophoresis of metabolically labeled astrocytes exposed to H showed induction of an approximate to 78-kDa polypeptide that demonstrated sequence identity with glucose-regulated protein (GRP) 78. Cell lysates from H/R astrocytes displayed induction of neuroprotective interleukin (IL) 6, which was present in a high-molecular-weight complex also containing GRP78, suggesting that GRP78 might be functioning as a chaperone during cellular stress consequent on H/R. Introduction of antisense oligonucleotide to GRP78 into astrocytes prevented expression of the protein and suppressed H/R-induced astrocyte release of IL-6 by approximate to 50%. These data indicate that modulation of astrocyte properties during oxygen deprivation results, in part, from intracellular glucose depletion and subsequent expression of GRP78, which sustains generation of neuroprotective IL-6 under the stress of H/R.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:38:42