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Titolo:
DOUBLE-CONTRAST MR-IMAGING OF REPERFUSED PORCINE MYOCARDIAL-INFARCTION - AN EXPERIMENTAL-STUDY USING GD-DTPA-BMA AND DY-DTPA-BMA
Autore:
NILSSON S; WIKSTROM G; ERICSSON A; WIKSTROM M; OKSENDAL A; WALDENSTROM A; HEMMINGSSON A;
Indirizzi:
UNIV UPPSALA,AKAD SJUKHUSET,DEPT DIAGNOST RADIOL S-75185 UPPSALA SWEDEN UNIV UPPSALA,AKAD SJUKHUSET,DEPT INTERNAL MED S-75185 UPPSALA SWEDEN NYCOMED IMAGING AS OSLO NORWAY UMEA UNIV HOSP,DEPT INTERNAL MED S-90185 UMEA SWEDEN
Titolo Testata:
Acta radiologica
fascicolo: 1, volume: 37, anno: 1996,
pagine: 27 - 35
SICI:
0284-1851(1996)37:1<27:DMORPM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSVERSE RELAXATION-TIME; CORONARY-OCCLUSION; MAGNETIC-RESONANCE; INJURY; HEMORRHAGE; PARTICLES; BLOOD;
Keywords:
HEART, INFARCTION; MR REPERFUSION; CONTRAST MEDIA, EXPERIMENTAL; GD-DTPA-BMA; DY-DTPA-BMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S. Nilsson et al., "DOUBLE-CONTRAST MR-IMAGING OF REPERFUSED PORCINE MYOCARDIAL-INFARCTION - AN EXPERIMENTAL-STUDY USING GD-DTPA-BMA AND DY-DTPA-BMA", Acta radiologica, 37(1), 1996, pp. 27-35

Abstract

Purpose: Myocardial infarctions were induced in 12 pigs to investigate whether a double-contrast method, combining a positive and a negative MR contrast agent, could improve the visualization of reperfused myocardial infarctions. Material and Methods: All 12 pigs were subjected to 80 min of occlusion followed by reperfusion. In the double-contrastgroup (6 pigs), Gd-DTPA-BMA (0.3 mmol/kg b.w.) and Dy-DTPA-BMA (1.0 mmol/kg b.w.) were administered i.v. after 30 min of reperfusion. In the remaining 6 pigs, a single injection of Gd-DTPA-BMA (0.3 mmol/kg b.w.) was given after 30 min of reperfusion. All pigs were sacrificed 10 min postcontrast injection, corresponding to a reperfusion time of 40 min. The hearts were excised and imaged with MR. The concentrations ofGd and Dy were measured in infarcted and nonischaemic myocardium using ICP-AES. Results and Conclusion: Contrast media concentrations were more than 4-fold higher in infarcted compared with nonischaemic myocardium. The infarctions were best shown on T1-weighted images, and therewere no differences between the double and single contrast groups. Inthe T2-weighted images, the infarctions were significantly better visualized in the double-contrast group, due to a Dy-induced signal intensity loss in nonischaemic myocardium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:24:56