Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MYOCARDIAL-CELL DEATH IN REPERFUSED AND NONREPERFUSED MYOCARDIAL INFARCTIONS - MR-IMAGING WITH DYSPROSIUM-DTPA-BMA IN THE PIG
Autore:
NILSSON S; WIKSTROM G; ERICSSON A; WIKSTROM M; OKSENDAL A; WALDENSTROM A; HEMMINGSSON A;
Indirizzi:
UNIV UPPSALA,AKAD SJUKHUSET,DEPT DIAGNOST RADIOL S-75185 UPPSALA SWEDEN UNIV UPPSALA,AKAD SJUKHUSET,DEPT INTERNAL MED S-75185 UPPSALA SWEDEN NYCOMED IMAGING AS OSLO NORWAY UMEA UNIV HOSP,DEPT INTERNAL MED S-90185 UMEA SWEDEN
Titolo Testata:
Acta radiologica
fascicolo: 1, volume: 37, anno: 1996,
pagine: 18 - 26
SICI:
0284-1851(1996)37:1<18:MDIRAN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC-INJURY; CONTRAST-MEDIUM; BLOOD; DIFFERENTIATION; ULTRASTRUCTURE;
Keywords:
HEART INFARCTION; MR; REPERFUSION; CONTRAST MEDIA EXPERIMENTAL; DY-DTPA-BMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S. Nilsson et al., "MYOCARDIAL-CELL DEATH IN REPERFUSED AND NONREPERFUSED MYOCARDIAL INFARCTIONS - MR-IMAGING WITH DYSPROSIUM-DTPA-BMA IN THE PIG", Acta radiologica, 37(1), 1996, pp. 18-26

Abstract

Purpose: To investigate whether Dy-DTPA-BMA-enhanced MR imaging wouldpermit identification of myocardial cell death, myocardial infarctionwas induced in 12 domestic pigs. Material and Methods: In 6 pigs withirreversible cell damage, Dy-DTPA-BMA (1.0 mmol/kg b.w.) was administered i.v. 70 min after coronary occlusion. In 6 other pigs, the infarctions were reperfused 80 min after the occlusion, followed by injection of Dy DTPA-BMA after 30 min of reperfusion. In 4 additional pigs, the hearts were reperfused after 2 min of occlusion. All 16 pigs were sacrificed 10 min after the injection of Dy-DTPA-BMA. The hearts were excised and imaged with MR. Results: Reversibly injured myocardium couldnot be distinguished from adjacent nonischaemic myocardium after the administration of Dy-DTPA-BMA. Reperfused, infarcted myocardium demonstrated a high signal intensity in the proton-density- and T2-weighted sequences, despite a 5-fold higher Dy concentration compared with bothnonreperfused infarcted and nonischaemic myocardium. Conclusion: Thislack of susceptibility effect in infarcted myocardium, due to a homogeneous distribution of Dy, indicates the usefulness of Dy as a marker of tissue viability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:32:47