Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FROM TARGETS TO GENES - A BRIEF-HISTORY OF RADIOSENSITIVITY
Autore:
STEEL GG;
Indirizzi:
CANC RES INST SUTTON SURREY ENGLAND
Titolo Testata:
Physics in medicine and biology
fascicolo: 2, volume: 41, anno: 1996,
pagine: 205 - 222
SICI:
0031-9155(1996)41:2<205:FTTG-A>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HETEROZYGOUS AUTOSOMAL LOCUS; DOUBLE-STRAND BREAKS; HUMAN-TUMOR CELLS; DOSE-RATE; MAMMALIAN-CELLS; INTRINSIC RADIOSENSITIVITY; CHROMOSOME-ABERRATIONS; RADIATION SENSITIVITY; HUMAN FIBROBLASTS; CYTOTOXIC AGENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
84
Recensione:
Indirizzi per estratti:
Citazione:
G.G. Steel, "FROM TARGETS TO GENES - A BRIEF-HISTORY OF RADIOSENSITIVITY", Physics in medicine and biology, 41(2), 1996, pp. 205-222

Abstract

The biological work of Douglas Lea spanned the period from 1934 to his early death in 1947, and during this short period he made important contributions to the theory of radiation action. He interpreted experimental data relating to the effects of radiation on viruses, bacteria,bean roots, etc in terms of the inactivation of discrete targets, which he identified with cellular genes. He thus laid the foundation of much subsequent research. It is now well recognized that mammalian cells differ substantially in radiosensitivity, especially in the low-doseregion of the survival curve. The dependence of radiosensitivity on dose rate has been widely studied; this has practical significance for clinical radiotherapy as well as mechanistic implications. Since Lea'stime there have been a number of efforts to describe models that can relate cell killing to radiation dose, dose rate, and track structure. So far these have not led to a comprehensive and widely accepted picture. Microdosimetric considerations lead to the concept of differing severity of lesions induced in DNA. Much is known about the sequence ofprocesses that subsequently lead to cell inactivation: this can be divided into phases of induction, processing, and manifestation. Chromosomal events are currently attracting much attention, as they did in Lea's time. Considerable progress has also been made in identifying genes that control the repair of radiation damage. It has been found that mutation is frequently associated with the loss of a large segment of the genome around the damage site and this will have important implications for interactive processes between particle tracks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:57:09