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Titolo:
INHIBITORY EFFECTS OF ACTIVIN ON THE GROWTH AND MORPHOGENESIS OF PRIMARY AND TRANSFORMED MAMMARY EPITHELIAL-CELLS
Autore:
LIU QY; NIRANJAN B; GOMES P; GOMM JJ; DAVIES D; COOMBES RC; BULUWELA L;
Indirizzi:
CHARING CROSS & WESTMINSTER MED SCH,DEPT MED ONCOL,FULHAM PALACE RD LONDON W6 8RF ENGLAND CHARING CROSS & WESTMINSTER MED SCH,DEPT MED ONCOL LONDON W6 8RF ENGLAND CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM LONDON W6 8RF ENGLAND INST CANC RES,DIV CELL BIOL & EXPT PATHOL SUTTON SM2 5NG SURREY ENGLAND IMPERIAL CANC RES FUND,FACS ANAL LAB LONDON WC2A 3PX ENGLAND
Titolo Testata:
Cancer research
fascicolo: 5, volume: 56, anno: 1996,
pagine: 1155 - 1163
SICI:
0008-5472(1996)56:5<1155:IEOAOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERINE THREONINE KINASE; ERYTHROID-DIFFERENTIATION FACTOR; FACTOR-BETA; MESSENGER-RNA; XENOPUS EMBRYOGENESIS; MYOEPITHELIAL CELLS; EXPRESSION CLONING; II RECEPTOR; GLAND; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
Q.Y. Liu et al., "INHIBITORY EFFECTS OF ACTIVIN ON THE GROWTH AND MORPHOGENESIS OF PRIMARY AND TRANSFORMED MAMMARY EPITHELIAL-CELLS", Cancer research, 56(5), 1996, pp. 1155-1163

Abstract

Activin is a member of the transforming growth factor beta superfamily, which is known to have activities involved in regulating differentiation and development. By using reverse transcription-PCR analysis on immunoaffinity-purified human breast cells, we have found that activinbeta a and activin type II receptor are expressed by myoepithelial cells, whereas no expression was detected in other breast cell types. Inexamining 15 breast cell lines, we have found only four (HBL-100, MCF10-A, PMC-42, and BT 20) to be positive for activin beta a mRNA, whereas all expressed the activin type II receptor, Furthermore, we have found activin A to be a potent growth inhibitor of MCF-7 cells (at 2 ng/ml), where it causes an arrest in G(1). Activin A does not appear to have an effect on the cell cycle of primary myoepithelial or luminal cells. However, we demonstrate that activin is an inhibitor of tubule formation by human mammary organoids in vitro. These are the first observations of activin and activin receptor in the normal human breast andin human breast cell lines and suggest a role for activin in mammary cell growth and morphogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 09:45:20