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Titolo:
NITRIC-OXIDE MEDIATES MITOGENIC EFFECT OF VEGF ON CORONARY VENULAR ENDOTHELIUM
Autore:
MORBIDELLI L; CHANG CH; DOUGLAS JG; GRANGER HJ; LEDDA F; ZICHE M;
Indirizzi:
UNIV FLORENCE,DEPT PHARMACOL,VIALE MORGAGNI 65 I-50134 FLORENCE ITALY UNIV FLORENCE,DEPT PRECLIN & CLIN PHARMACOL I-50134 FLORENCE ITALY CASE WESTERN RESERVE UNIV,SCH MED,DIV HYPERTENS CLEVELAND OH 44106 TEXAS A&M UNIV,MICROCIRULAT RES INST COLLEGE STN TX 77843 TEXAS A&M UNIV,DEPT MED PHYSIOL COLLEGE STN TX 77843
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 39, anno: 1996,
pagine: 411 - 415
SICI:
0363-6135(1996)39:1<411:NMMEOV>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY FACTOR; CELL GROWTH-FACTOR; TUMOR ANGIOGENESIS; CAPILLARY GROWTH; TYROSINE KINASE; BINDING; RELEASE; IDENTIFICATION; EXPRESSION; RECEPTOR;
Keywords:
ANGIOGENESIS; GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE; GROWTH FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
L. Morbidelli et al., "NITRIC-OXIDE MEDIATES MITOGENIC EFFECT OF VEGF ON CORONARY VENULAR ENDOTHELIUM", American journal of physiology. Heart and circulatory physiology, 39(1), 1996, pp. 411-415

Abstract

Vascular endothelial growth factor (VEGF) is a secreted protein that is a specific growth factor for endothelial cells. We have recently demonstrated that nitric oxide (NO) donors and vasoactive peptides promoting NO-mediated vasorelaxation induce angiogenesis in vivo as well asendothelial cell growth and motility in vitro; in contrast, inhibitors of NO synthase suppress angiogenesis. In this study we investigated the role of NO in mediating the mitogenic effect of VEGF on cultured microvascular endothelium isolated from coronary postcapillary venules. VEGF induced a dose-dependent increase in cell proliferation and DNA synthesis. The role of NO was determined by monitoring proliferation or guanosine 3',5'-cyclic monophosphate (cGMP) levels in the presence and absence of NO synthase blockers. The proliferative effect evoked byVEGF was reduced by pretreatment of the cells with NO synthase inhibitors. Exposure of the cells to VEGF induced a significant increment incGMP levels. This effect was potentiated by superoxide dismutase addition and was abolished by NO synthase inhibitors. VEGF stimulates proliferation of postcapillary endothelial cells through the production ofNO and cGMP accumulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:13:19