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Titolo:
ENDOTHELIN-1 CONSTRICTS FETOPLACENTAL MICROCIRCULATION AND DECREASES FETAL O-2 CONSUMPTION IN SHEEP
Autore:
ADAMSON SL; WHITELEY KJ; LANGILLE BL;
Indirizzi:
UNIV TORONTO,SAMUEL LUNENFELD RES INST,MT SINAI HOSP,PROGRAM DEV & FETAL HLTH,RM 138-P TORONTO ON M5G 1X5 CANADA UNIV TORONTO,DEPT OBSTET & GYNECOL,MT SINAI HOSP TORONTO ON M5G 1X5 CANADA UNIV TORONTO,DEPT PATHOL,MT SINAI HOSP TORONTO ON M5G 1X5 CANADA
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 39, anno: 1996,
pagine: 16 - 23
SICI:
0363-6135(1996)39:1<16:ECFMAD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
UMBILICAL BLOOD-FLOW; ANGIOTENSIN-II; VASCULAR-RESISTANCE; RESPONSES; CIRCULATION; INFUSION; LAMBS; LOCALIZATION; PRESSURE; PLACENTA;
Keywords:
OVINE; HEMODYNAMICS; CARDIOVASCULAR; UMBILICAL ARTERY; UMBILICAL VEIN; PLACENTA; BLOOD PRESSURE; HEART RATE; VASOCONSTRICTION; PULSATILITY INDEX; ENDOTHELIN; METABOLIC RATE; VASCULAR RESISTANCE; VASCULAR IMPEDANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Adamson et al., "ENDOTHELIN-1 CONSTRICTS FETOPLACENTAL MICROCIRCULATION AND DECREASES FETAL O-2 CONSUMPTION IN SHEEP", American journal of physiology. Heart and circulatory physiology, 39(1), 1996, pp. 16-23

Abstract

Endothelin-1 produced by umbilicoplacental tissues may regulate fetalplacental perfusion. To investigate its site of action, we measured segmental resistance in this bed in unanesthetized fetal sheep near term during fetal endothelin-1 infusion. A 15-min intravenous infusion ofendothelin-1 at 1 mu g/min significantly increased fetal blood pressure in the aorta (+33%), cotyledon artery and vein, and inferior vena cava, and endothelin-1 decreased fetal heart rate (-40%). Vascular resistance in the placental microcirculation increased significantly (+332%), but smaller increases in resistance of the umbilical artery and vein were not significant. Nevertheless, the stiffness of the umbilical arterial wall appeared to increase because vascular input impedance increased significantly both at the heart rate frequency (+85%) and whenaveraged >2 Hz (characteristic impedance; +138%). Mean blood flow in the umbilical artery decreased by 64%, and the flow pulsatility index increased 137% (P < 0.05 for both). Despite the large decrease in placental perfusion, there was no significant change in descending aortic oxygen tension or oxygen content, because fetal oxygen consumption wasreduced by 40%. We conclude that endothelin-1 is a potent constrictorof the placental microcirculation in sheep. Endothelin-1 also decreases fetal oxygen consumption by an unknown mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:45:04