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Titolo:
RISKS OF NON-HODGKINS-LYMPHOMA, MULTIPLE-MYELOMA, AND LEUKEMIA ASSOCIATED WITH COMMON MEDICATIONS
Autore:
DOODY MM; LINET MS; GLASS AG; ROCHELLE RE; POTTERN LM; RUSH BB; BOICE JD; FRAUMENI JF; FRIEDMAN GD;
Indirizzi:
NCI,RADIAT EPIDEMIOL BRANCH,EPIDEMIOL & BIOSTAT PROGRAM,EXECUT PLAZA N,ROOM 408 BETHESDA MD 20892
Titolo Testata:
Epidemiology
fascicolo: 2, volume: 7, anno: 1996,
pagine: 131 - 139
SICI:
1044-3983(1996)7:2<131:RONMAL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; ENDOMETRIAL CARCINOMA; RHEUMATOID-ARTHRITIS; BREAST-CANCER; CONJUGATED ESTROGENS; EXOGENOUS ESTROGEN; THERAPY; CARCINOGENICITY; DRUGS; AGRANULOCYTOSIS;
Keywords:
NON-HODGKINS LYMPHOMA; MULTIPLE MYELOMA; LEUKEMIA; PRESCRIPTIONS (DRUG); DRUGS (NONPRESCRIPTION); HEALTH MAINTENANCE ORGANIZATIONS; CASE CONTROL STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Doody et al., "RISKS OF NON-HODGKINS-LYMPHOMA, MULTIPLE-MYELOMA, AND LEUKEMIA ASSOCIATED WITH COMMON MEDICATIONS", Epidemiology, 7(2), 1996, pp. 131-139

Abstract

We utilized data from two Kaiser Permanente medical care programs to evaluate risks of hematopoietic and lymphoproliferative (HLP) malignancies after use of 14 common medications. The subjects were adult casesof non-Hodgkin's lymphoma (NHL) (N = 94), multiple myeloma (N = 159),and leukemia (N = 257) and individually matched controls (N = 695). Abstractors reviewed medical records and recorded med ication notations. Using a minimum 5-year exposure lag be tween first notation and malignancy diagnosis, the risk of NHL was greater among plan members who were prescribed amphet amines [odds ratio (OR) = 2.2; 95% confidence interval (CI) = 1.1-4.8], lidocaine (OR = 2.6; 95% CI = 1.2-5.5), and meprobamate (OR = 2.1; 95% CI = 1.03-4.3). The risk of NHL rose with increasing number of medical record notations for amphetamines; however, there was no association with number of notations for lidocaine or meprobamate. The odds ratio for total leukemia was decreased among patients who took chloramphenicol (OR = 0.4; 95% CI = 0.2-0.97).

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Documento generato il 12/07/20 alle ore 12:21:58