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Titolo:
EFFECT OF THE HISTAMINE-RECEPTOR ANTAGONIST ANTAZOLINE ON REPRODUCTIVE FUNCTION IN MALE-RATS
Autore:
RATNASOORIYA WD; GOONASINGHE NN; WADSWORTH RM;
Indirizzi:
UNIV COLOMBO,DEPT ZOOL COLOMBO 03 SRI LANKA UNIV STRATHCLYDE,DEPT PHYSIOL & PHARMACOL GLASGOW G1 1XW LANARK SCOTLAND
Titolo Testata:
Medical science research
fascicolo: 1, volume: 24, anno: 1996,
pagine: 63 - 66
SICI:
0269-8951(1996)24:1<63:EOTHAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Keywords:
ANTAZOLINE; HISTAMINE RECEPTOR ANTAGONIST; LIBIDO; SEXUAL PERFORMANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
W.D. Ratnasooriya et al., "EFFECT OF THE HISTAMINE-RECEPTOR ANTAGONIST ANTAZOLINE ON REPRODUCTIVE FUNCTION IN MALE-RATS", Medical science research, 24(1), 1996, pp. 63-66

Abstract

Antazoline, a histamine H-1-receptor antagonist was investigated for its effects on male reproductive function (libido, sexual behaviour and fertility) using rats as subjects. These parameters were assessed using serial mating and masculine copulatory behaviour techniques. The drug was administered orally, thrice a day, in 3 different concentrations (0.5, 1.0 or 2.0 mg kg(-1)). In the mating test, all doses of antazoline tested caused significant inhibition in libido (in terms of indices of libido and fertility) on days 3, and 7 of treatment. Antazoline1 mg kg(-1), in addition depressed these two parameters on day 7 following treatment. However, antazoline treated rats that did mate displayed normal ejaculatory competence (in terms of vaginal sperm count index) and fertility (in terms of quantal pregnancy and number of uterineimplants) without significant changes in pre- and post-implantation losses and fetal growth. In the masculine sexual behaviour test antazoline 1 mg kg(-1) caused significant reduction in all the parameters of behaviour observed (% mounting, % intromitting, % ejaculating, copulatory efficiency, intercopulatory interval, mount latency, intromission latency, ejaculatory latency, mount frequency and intromission frequency). Antazoline did not exhibit significant antiandrogenic action (in terms of wet sexual accessory organ weights) or sedative activity (in the rat-hole board test). It is concluded that antagonism of histamineH-1-receptors with antazoline inhibits libido and sexual performance in male rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:56:41