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Titolo:
EFFECTS OF ANANDAMIDE AND ARACHIDONIC-ACID ON SPECIFIC BINDING OF (-PN200-110, DILTIAZEM AND (-)-DESMETHOXYVERAPAMIL TO L-TYPE CA2+ CHANNEL())
Autore:
SHIMASUE K; URUSHIDANI T; HAGIWARA M; NAGAO T;
Indirizzi:
UNIV TOKYO,FAC PHARMACEUT SCI,DEPT PHARMACOL & TOXICOL,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN UNIV TOKYO,FAC PHARMACEUT SCI,DEPT PHARMACOL & TOXICOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 296, anno: 1996,
pagine: 347 - 350
SICI:
0014-2999(1996)296:3<347:EOAAAO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM CHANNELS; RECEPTOR;
Keywords:
ANANDAMIDE; CA2+ CHANNEL; ARACHIDONIC ACID; [H-3] (+)-PN200-110; [H-3] DILTIAZEM; [H-3] (-)-DESMETHOXYVERAPAMIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
K. Shimasue et al., "EFFECTS OF ANANDAMIDE AND ARACHIDONIC-ACID ON SPECIFIC BINDING OF (-PN200-110, DILTIAZEM AND (-)-DESMETHOXYVERAPAMIL TO L-TYPE CA2+ CHANNEL())", European journal of pharmacology, 296(3), 1996, pp. 347-350

Abstract

We examined the effects of anandamide (N-arachidonoylethanolamine) onthe binding of three types of Ca2+ channel antagonists for L-type Ca2 channel, i.e., 1,4-dihydropyridine, 1,5-benzothiazepine and phenylalkylamine, to rabbit skeletal muscle membranes. Anandamide inhibited the binding of all three ligands. Arachidonic acid, a putative metabolite or a precursor of anandamide, inhibited 1,4-dihydropyridine binding,whereas it augmented both 1,5-benzothiazepine and phenylalkylamine binding. The involvement of prostaglandins synthesized from arachidonic acid was considered to be minor. These findings indicate that both anandamide and arachidonic acid interact not only with 1,4-dihydropyridine but also with 1,5-benzothiazepine and phenylalkylamine binding sitesas a common feature of unsaturated lipids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:50:22