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Titolo:
LONGITUDINAL SERUM HIV RNA QUANTIFICATION - CORRELATION TO VIRAL PHENOTYPE AT SEROCONVERSION AND CLINICAL OUTCOME
Autore:
KATZENSTEIN TL; PEDERSEN C; NIELSEN C; LUNDGREN JD; JAKOBSEN PH; GERSTOFT J;
Indirizzi:
RIGSHOSP,DEPT INFECT DIS,TAGENSVEJ 20 DK-2200 COPENHAGEN N DENMARK HVIDOVRE UNIV HOSP,DEPT INFECT DIS HVIDOVRE DENMARK STATE SERUM INST COPENHAGEN DENMARK FREDERIKSBERG UNIV HOSP,DEPT MED FREDERIKSBERG DENMARK
Titolo Testata:
AIDS
fascicolo: 2, volume: 10, anno: 1996,
pagine: 167 - 173
SICI:
0269-9370(1996)10:2<167:LSHRQ->2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSEQUENT COURSE; INFECTION; CONSEQUENCES;
Keywords:
HIV; HIV RNA; VIRAL LOAD; SEROCONVERSION; VIRAL PHENOTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Katzenstein et al., "LONGITUDINAL SERUM HIV RNA QUANTIFICATION - CORRELATION TO VIRAL PHENOTYPE AT SEROCONVERSION AND CLINICAL OUTCOME", AIDS, 10(2), 1996, pp. 167-173

Abstract

Objective: To investigate the longitudinal changes in serum HIV RNA, and to clarify whether the viral load early in infection has a predictive value for the clinical outcome; also, to correlate viral phenotypeat seroconversion and changes in CD4 cell counts with viral burden. Design: Twenty seroconverters with HIV isolates available at seroconversion had HIV RNA quantified by polymerase chain reaction (PCR) at seroconversion and thereafter every 6 months. Mean follow-up time was 65 months. Patients were classified according to viral phenotype at seroconversion, time to AIDS progression, serum viral load within the first year (less or more than 1.5 x 10(4) copies/ml). Results: High viral load at seroconversion was followed by a significant decline within the first months (P < 0.0005). Decline to < 1.5 x 10(4) copies/ml was correlated with slower progression to AIDS (P < 0.05). A correlation between the rate of CD4 decline and the median viral load during the ensuing viral load plateau phase was also shown (P < 0.05). Subsequent to this phase the viral burden increased. Rapid progressors had higher viral load than slow- or non-progressors; this was particularly pronouncedlate in infection. Harbouring syncytium-inducing (SI) virus at seroconversion was associated with faster progression to AIDS than non-SI (NSI; P < 0.005). The increased in vitro replication rate of SI over NSIwas not translated into significantly higher serum HIV RNA. Conclusion: Serum HIV RNA is high around the time of seroconversion. A significant decline within the first months hereafter is followed by a plateauphase, which in turn is followed by an increase in HIV RNA. HIV RNA early in infection has a predictive value for the clinical outcome. Theincreased virulence of SI over NSI virus did not translate into significantly higher HIV RNA values.

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Documento generato il 27/11/20 alle ore 15:43:28