Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE PROGNOSTIC-SIGNIFICANCE OF SERUM VIRAL LOAD, CODON-215 REVERSE-TRANSCRIPTASE MUTATION AND CD4-CELLS ON PROGRESSION OF HIV DISEASE IN A DOUBLE-BLIND-STUDY OF THYMOPENTIN( T)
Autore:
MERIGAN TC; HIRSCH RL; FISHER AC; MEYERSON LA; GOLDSTEIN G; WINTERS MA;
Indirizzi:
STANFORD UNIV,SCH MED,CTR AIDS RES,DEPT MED STANFORD CA 94305 STANFORD UNIV,MED CTR,CTR AIDS RES STANFORD CA 94305 IMMUNOBIOL RES INST ANNANDALE NJ 00000
Titolo Testata:
AIDS
fascicolo: 2, volume: 10, anno: 1996,
pagine: 159 - 165
SICI:
0269-9370(1996)10:2<159:TPOSVL>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; BETA-2-MICROGLOBULIN LEVEL; LYMPHOCYTE COUNT; CONTROLLED TRIAL; INFECTION; ZIDOVUDINE; AIDS; DECLINE; INVITRO; MICE;
Keywords:
ASYMPTOMATIC; RESISTANCE; THYMOPENTIN; VIRAL LOAD; HIV RNA; ZIDOVUDINE; DISEASE PROGRESSION; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
T.C. Merigan et al., "THE PROGNOSTIC-SIGNIFICANCE OF SERUM VIRAL LOAD, CODON-215 REVERSE-TRANSCRIPTASE MUTATION AND CD4-CELLS ON PROGRESSION OF HIV DISEASE IN A DOUBLE-BLIND-STUDY OF THYMOPENTIN( T)", AIDS, 10(2), 1996, pp. 159-165

Abstract

Objective: To determine in asymptomatic HIV-infected subjects the prognostic value of virion reverse transcriptase (RT) codon 215 mutation,serum HIV RNA level, CD4+ T-cell count and immune complex dissociated(ICD) p24 level. The retrospective evaluation of thymopentin treatment effect on subjects in high risk groups for progression was a secondary objective. Participants: Zidovudine (ZDV)-experienced asymptomatic HIV-infected subjects (n = 352) who had been enrolled in a 48-week placebo-controlled double-blind trial of thymopentin treatment were studied. Methods: Post hoc analyses were conducted to determine which subjects at study entry were at greater risk for progression to AIDS-related complex (ARC), AIDS or death, and to determine the effect of treatment on these subjects. Four potential prognostic variables (virion RT codon 215 mutation, circulating HIV virion RNA copies, CD4+ T-cell count, and ICD p24) were evaluated by dichotomizing subjects for each variable based on the median of the observed values. CD4+ T-cell count wasevaluated prospectively, whereas frozen samples were evaluated under blinded conditions for the other variables after the study was completed. Results: The presence of the codon 215 mutation [P = 0.044; relative hazard (RH), 2.6], greater than or equal to 20 000 HIV RNA copies/ml (P = 0.002; RH, 5.5), and < 350 CD4+ cells 10(6)/l (P = 0.042; RH, 2.2) were prognostic factors, and greater than or equal to 30 pg/ml ICDp24 level (P = 0.52; RH, 1.4) was not a prognostic factor in predicting progression. Subjects were prestratified by previous ZDV use (less than or equal to 6 or > 6 months). Across both strata thymopentin delayed treatment progression to ARC, AIDS, or death (P = 0.015; RH, 3.0). This effect was magnified in the ZDV-experienced subjects at greater risk, where thymopentin delayed progression compared to placebo in thepresence of the codon 215 mutation (P = 0.007; RH, 10.1), greater than or equal to 20 000 RNA copies/ml (P = 0.012; RH, 8.9), and CD4+ T-cell count < 350 x 10(6)/l (P = 0.005; RH, 10.4). Conclusions: Codon 215mutation, serum HIV RNA and CD4 T-cell count are independent predictors of progression in ZDV-experienced asymptomatic subjects. Furthermore, thymopentin delays HIV disease progression in the presence of a keyZDV resistance mutation as well as high viral load and low CD4+ T-cell counts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:40:34