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Titolo:
DIFFERENTIAL REGULATION OF PUTATIVE K-ATPASE BY LOW-K+ DIET AND CORTICOSTEROIDS IN RAT DISTAL COLON AND KIDNEY()
Autore:
JAISSER F; ESCOUBET B; COUTRY N; EUGENE E; BONVALET JP; FARMAN N;
Indirizzi:
FAC MED XAVIER BICHAT,INSERM U246,INST FEDERAT RECH CELLULES EPITHELIALES,BP 416 F-75870 PARIS 18 FRANCE FAC MED XAVIER BICHAT,INSERM U246,INST FEDERAT RECH CELLULES EPITHELIALES F-75870 PARIS 18 FRANCE FAC MED XAVIER BICHAT,INSERM U426,INST FEDERAT RECH CELLULES EPITHELIALES F-75870 PARIS 18 FRANCE
Titolo Testata:
American journal of physiology. Cell physiology
fascicolo: 2, volume: 39, anno: 1996,
pagine: 679 - 687
SICI:
0363-6143(1996)39:2<679:DROPKB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE POTASSIUM ABSORPTION; MEDULLARY COLLECTING DUCT; ADENOSINE-TRIPHOSPHATASE; GASTRIC H+,K+-ATPASE; RUBIDIUM ABSORPTION; PROTON SECRETION; APICAL MEMBRANE; OUABAIN; DEPLETION; TUBULE;
Keywords:
POTASSIUM ABSORPTION; P-ADENOSINE-TRIPHOSPHATASE; TIGHT EPITHELIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
F. Jaisser et al., "DIFFERENTIAL REGULATION OF PUTATIVE K-ATPASE BY LOW-K+ DIET AND CORTICOSTEROIDS IN RAT DISTAL COLON AND KIDNEY()", American journal of physiology. Cell physiology, 39(2), 1996, pp. 679-687

Abstract

K+ homeostasis depends on K+ absorption in digestive and renal epithelia. Recently, a cDNA encoding for a putative K+-adenosinetriphosphatase (ATPase) alpha-subunit has been characterized. We studied its expression by ribonuclease protection assay and in situ hybridization in the distal colon and the kidney of rats in various physiological states. In the distal colon of control rats, high expression of the colonic putative K+-ATPase mRNA was restricted to the surface epithelial cells. A low-K+ diet did not modify this expression, adrenalectomy decreasedit, and aldosterone or dexamethasone treatment for 2 days restored normal levels. In the kidney of control rats, levels of K+-ATPase mRNA were very low. A low-K+ diet revealed a clear mRNA expression, which isconsistent with a recent report [J. A. Kraut, F. Starr, G. Sachs, andM. Reuben. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37):F581-F587, 1995]. This expression was restricted to the outer medullary collecting duct, presumably in principal cells. Changes in corticosteroid status did not influence the renal expression. Our results, together with previous studies on K-+ absorption and K+-ATPase activity, suggest that more than a single molecular form of K+-ATPase is likely to be responsible for the regulation of K+ absorption in the colon anddistal nephron.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:33:27