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Titolo:
NONUNIFORM SYMPATHETIC-NERVE RESPONSES TO INTRAVENOUS HYPERTONIC SALINE INFUSION
Autore:
WEISS ML; CLAASSEN DE; HIRAI T; KENNEY MJ;
Indirizzi:
KANSAS STATE UNIV,DEPT ANAT & PHYSIOL,1600 DENISON AVE MANHATTAN KS 66506 KANSAS STATE UNIV,DEPT ANAT & PHYSIOL MANHATTAN KS 66506
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1-2, volume: 57, anno: 1996,
pagine: 109 - 115
SICI:
0165-1838(1996)57:1-2<109:NSRTIH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINOAORTIC-DENERVATED RATS; CONSCIOUS DOGS; PERIPHERAL HYPEROSMOLALITY; BAROREFLEX INHIBITION; ARGININE VASOPRESSIN; PLASMA VASOPRESSIN; BARORECEPTORS; RELEASE; SYSTEM; NACL;
Keywords:
SYMPATHETIC NERVE DISCHARGE; HYPERTONIC SALINE; SPRAGUE-DAWLEY RAT; CHLORALOSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Weiss et al., "NONUNIFORM SYMPATHETIC-NERVE RESPONSES TO INTRAVENOUS HYPERTONIC SALINE INFUSION", Journal of the autonomic nervous system, 57(1-2), 1996, pp. 109-115

Abstract

Peripheral hyperosmolality produced by the intravenous infusion of hypertonic saline (HTS) increases mean arterial blood pressure (MAP) in experimental animals. The mechanisms mediating the presser response have not been fully ascertained, but likely involve vasopressin and/or activation of the sympathetic nervous system. The primary aim of this study was to determine if HTS infusion produces regionally uniform or nonuniform changes in sympathetic nerve discharge (SND). For this purpose we recorded renal, splanchnic and lumbar SND during intravenous HTSinfusion (2.5 M NaCl, 10 mu l/100 g BW per min) in chloralose-anesthetized, Sprague-Dawley rats, In rats with intact arterial baroreceptors, HTS infusion significantly increased MAP (17 +/- 2 mmHg) and lumbar SND (29 +/- 13%) but reduced splanchnic (-52 +/- 7%) and renal SND (-33 +/- 8%). After sinoaortic denervation (SAD), FITS infusion significantly increased MAP (28 +/- 6 mmHg) and lumbar SND (27 +/- 9%) and decreased renal SND (-22 +/- 8%). The increase in lumbar SND occurred significantly sooner in SAD compared with baroreceptor-intact rats. In contrast, splanchnic SND remained unchanged from control levels during HTS infusion after SAD. These results demonstrate that I-ITS infusion produces regionally nonuniform changes in SND, and suggest that the presser and lumbar sympathoexcitatory responses to HTS infusion are opposed by the arterial baroreceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:09:51