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Titolo:
GLYCOPROTEIN-110, THE EPSTEIN-BARR-VIRUS HOMOLOG OF HERPES-SIMPLEX VIRUS GLYCOPROTEIN-B, IS ESSENTIAL FOR EPSTEIN-BARR-VIRUS REPLICATION IN-VIVO
Autore:
HERROLD RE; MARCHINI A; FRUEHLING S; LONGNECKER R;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,DEPT MICROBIOL IMMUNOL,303 E CHICAGO AVE CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT MICROBIOL IMMUNOL CHICAGO IL 60611 HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,VIROL PROGRAM BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT MED BOSTON MA 02115
Titolo Testata:
Journal of virology
fascicolo: 3, volume: 70, anno: 1996,
pagine: 2049 - 2054
SICI:
0022-538X(1996)70:3<2049:GTEHOH>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH TRANSFORMATION INVITRO; LATENT MEMBRANE PROTEIN-2A; LYMPHOCYTE INFECTION; MARMOSET LEUKOCYTES; HEPARAN-SULFATE; CELLS; TYPE-1; EBV; IDENTIFICATION; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Herrold et al., "GLYCOPROTEIN-110, THE EPSTEIN-BARR-VIRUS HOMOLOG OF HERPES-SIMPLEX VIRUS GLYCOPROTEIN-B, IS ESSENTIAL FOR EPSTEIN-BARR-VIRUS REPLICATION IN-VIVO", Journal of virology, 70(3), 1996, pp. 2049-2054

Abstract

The Epstein-Barr virus (EBV) glycoprotein gp110 has substantial aminoacid homology to gB of herpes simplex virus but localizes differentlywithin infected cells and is essentially undetectable in virions. To investigate whether gp110, like gB, is essential for EBV infection, a selectable marker was inserted within the gp110 reading frame, BALF4, and the resulting null mutant EBV strain, B95-110HYG, was recovered inlymphoblastoid cell lines (LCLs). While LCLs infected with the parental virus B95-8 expressed the gp110 protein product following productive cycle induction, neither full-length gp110 nor the predicted gp110 truncation product was detectable in B95-110HYG LCLs. Infectious virus could not be recovered from B95-110HYG LCLs unless gp110 was provided in trans. Rescued B95-110HYG virus latently infected and growth transformed primary B lymphocytes. Thus, gp110 is required for the production of transforming virus but not for the maintenance of transformation of primary B lymphocytes by EBV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:11:44