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Titolo:
VITAMIN-D, CALCIUM, AND SARCOIDOSIS
Autore:
SHARMA OP;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT PULM & CRIT CARE MED LOS ANGELES CA 90089
Titolo Testata:
Chest
fascicolo: 2, volume: 109, anno: 1996,
pagine: 535 - 539
SICI:
0012-3692(1996)109:2<535:VCAS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE-T ACTIVATION; SERUM 1,25-DIHYDROXYVITAMIN-D; BONE-FORMATION; HYPERCALCEMIA; METABOLISM; CALCITRIOL; PATIENT; PROLIFERATION; HORMONE; THERAPY;
Keywords:
ALVEOLAR MACROPHAGE; CALCITRIOL; CHLOROQUINE; HYPERCALCEMIA; HYPERCALCIURIA; KETOCONAZOLE; SARCOIDOSIS; VITAMIN-D;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
O.P. Sharma, "VITAMIN-D, CALCIUM, AND SARCOIDOSIS", Chest, 109(2), 1996, pp. 535-539

Abstract

Hypercalcemia occurs in about 10% of the patients with sarcoidosis; hypercalciuria is about three times more frequent. These abnormalities of calcium metabolism are due to dysregulated production of 1,25-(OH)(2)-D-3 (calcitriol) by activated macrophages trapped in pulmonary alveoli and granulomatous inflammation. Undetected hypercalcemia and hypercalciuria can cause nephrocalcinosis, renal stones, and renal failure. Corticosteriods cause prompt reversal of the metabolic defect. Chloroquine, hydroxychloroqune, and ketoconazole are the drugs that should be used if the patient fails to respond or develops dangerous side effects to corticosteroid therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:09:25