Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MISOPROSTOL AND RANITIDINE IN THE PREVENTION OF NSAID-INDUCED ULCERS - A PROSPECTIVE, DOUBLE-BLIND, MULTICENTER STUDY
Autore:
RASKIN JB; WHITE RH; JASZEWSKI R; KORSTEN MA; SCHUBERT TT; FORT JG; MCMILLEN J; MORELAND L; ORCHARD J; PATEL M; PATTERSON D; SAWAY A; SKOSEY J; STRADER K; TINDALL E; TRIADAFILOPOULOS G; YOUNG G; AARONSON R; AGRAWAL N; MCKEEVER C; BIRBARA C; CHEN S; CONAWAY D; DOCKHORN R; TARNAWSKI A; FLEISCHMANN R; JAIN A; KAINE J; KOLODNY AL; KATZ R; CALDWELL J; CHEATUM D;
Indirizzi:
UNIV MIAMI,JACKSON MEM MED CTR,SCH MED,1611 NW 12TH MIAMI FL 33136 DEPT VET AFFAIRS MED CTR MIAMI FL 00000 UNIV CALIF DAVIS DAVIS CA 95616 DEPT VET AFFAIRS MED CTR ALLEN PK MI 00000 DEPT VET AFFAIRS MED CTR NEW YORK NY 00000 MT SINAI MED CTR NEW YORK NY 10029 HENRY FORD HOSP DETROIT MI 48202 GD SEARLE & CO SKOKIE IL 60077
Titolo Testata:
The American journal of gastroenterology
fascicolo: 2, volume: 91, anno: 1996,
pagine: 223 - 227
SICI:
0002-9270(1996)91:2<223:MARITP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-INFLAMMATORY DRUGS; MUCOSAL DAMAGE; BLOOD-LOSS; ASPIRIN; COMPLICATIONS; INJURY; AGENTS; ANALOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Raskin et al., "MISOPROSTOL AND RANITIDINE IN THE PREVENTION OF NSAID-INDUCED ULCERS - A PROSPECTIVE, DOUBLE-BLIND, MULTICENTER STUDY", The American journal of gastroenterology, 91(2), 1996, pp. 223-227

Abstract

Objective: To compare ranitidine to misoprostol with respect to the prevention of gastric and duodenal ulcers in patients on chronic NSAID therapy. Methods: A multi-center, 8-wk, randomized, double-blind study, Eligible patients were on chronic NSAID therapy and were experiencing NSAID-related upper gastrointestinal (UGI) pain without UGI endoscopic evidence of gastric or duodenal ulcers, Patients enrolled in the study were randomized to either misoprostol 200 mu g q.i.d or ranitidine150 mg b.i.d. Follow-up UGI endoscopy was performed after 4 and 8 wk of treatment. Therapeutic failure was considered the development of a gastric or duodenal ulcer equal to or greater than 0.3 cm in diameter with perceptible depth. Results: Gastric ulcers were found in only 1/180 (0.56%) patient on misoprostol and in 11/194 (5.67%) patients on ranitidine, a difference that was statistically significant (p < 0.01), Duodenal ulcer rates were similar for the ranitidine (2/185 or 1.08%) and misoprostol (2/185 or 1.10%) groups. Conclusion: Misoprostol is significantly more effective than ranitidine in the prevention of NSAID-induced gastric ulcers. Ranitidine was as effective as misoprostol forthe prevention of NSAID-induced duodenal ulcers, Misoprostol should be used for prophylaxis against both gastric and duodenal ulceration inpatients on chronic NSAID therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:57:58