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Titolo:
NEW ANTIPSYCHOTICS - THE PRESENT STATUS
Autore:
GERLACH J; PEACOCK L;
Indirizzi:
ST HANS HOSP,INST BIOL PSYCHIAT,DEPT P DK-4000 ROSKILDE DENMARK RIGSHOSP,DEPT PSYCHIAT COPENHAGEN DENMARK
Titolo Testata:
International clinical psychopharmacology
, volume: 10, anno: 1995, supplemento:, 3
pagine: 39 - 48
SICI:
0268-1315(1995)10:<39:NA-TPS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-SCHIZOPHRENIC PATIENTS; RECEPTOR OCCUPANCY; DOPAMINE RECEPTOR; HALOPERIDOL; CLOZAPINE; RISPERIDONE; SULPIRIDE; CROSSOVER; SEROQUEL; PROFILE;
Keywords:
ANTIPSYCHOTICS; EXTRAPYRAMIDAL SYMPTOMS; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
J. Gerlach e L. Peacock, "NEW ANTIPSYCHOTICS - THE PRESENT STATUS", International clinical psychopharmacology, 10, 1995, pp. 39-48

Abstract

Until antipsychotics can be subdivided according to differentiated effects on psychic functions (for example on positive/negative symptoms and cognitive functions), the best classification seems to be one based upon receptor-binding profiles and the side effects that follow. Such a combined pharmacological-clinical approach appears fruitful to clinicians as well as pharmacologists. According to this classification the new antipsychotics can be subdivided into three main categories: the relatively pure dopamine antagonists (D-2 antagonists, including sulpiride and amisulpiride); the dopamine (D-2)-serotonin (5-HT2)-norepinephrine (alpha(1)) antagonists (risperidone, ziprazidone and sertindole); and the multireceptor antagonists (clozapine, olanzapine and seroquel). Clozapine is still the most potent antipsychotic and the least potent at inducing extrapyramidal symptoms. New drugs such as olanzapine, seroquel and sertindole represent the further development of clozapine's positive qualities, while risperidone and ziprasidone are dominated to a greater extent by relatively traditional dopamine D-2 receptor blockade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:28:55