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Titolo:
GLUTAMATE RECEPTORS MEDIATE DYNAMIC REGULATION OF NITRIC-OXIDE SYNTHASE EXPRESSION IN CEREBELLAR GRANULE CELLS
Autore:
BAADER SL; SCHILLING K;
Indirizzi:
UNIV ULM,DEPT ANAT & CELL BIOL,ALBERT EINSTEIN ALLEE 11 D-89069 ULM GERMANY UNIV ULM,DEPT ANAT & CELL BIOL D-89069 ULM GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 4, volume: 16, anno: 1996,
pagine: 1440 - 1449
SICI:
0270-6474(1996)16:4<1440:GRMDRO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; NERVOUS-SYSTEM; NADPH-DIAPHORASE; FREE CALCIUM; TIME-COURSE; BRAIN; MESSENGER; NEURONS; MOSSY; DEPOLARIZATION;
Keywords:
CEREBELLUM; GRANULE CELLS; PURKINJE CELLS; MOSSY FIBER; NITRIC OXIDE SYNTHASE; GLUTAMATE; NEUROTRANSMISSION; SIGNAL TRANSDUCTION; CALCIUM; VOLTAGE-DEPENDENT CA2+ CHANNELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Baader e K. Schilling, "GLUTAMATE RECEPTORS MEDIATE DYNAMIC REGULATION OF NITRIC-OXIDE SYNTHASE EXPRESSION IN CEREBELLAR GRANULE CELLS", The Journal of neuroscience, 16(4), 1996, pp. 1440-1449

Abstract

Nitric oxide (NO) is a multifaceted messenger molecule believed to beinvolved in neural plasticity and development. Within the cerebellum,the NO synthesizing enzyme, NO synthase (NOS), is expressed exclusively by granule cells and stellate/basket neurons. In the adult cerebellum, levels of NOS expression can be used to define discrete clusters of granule cell populations. Differential expression of NOS by granule cells temporally coincides with the establishment of afferent innervation of granule cells. In primary cerebellar cultures that comprise a functional network of glutamatergic and GABAergic cerebellar neurons, blockade of electrical activity by tetrodotoxin induced the expression of the neuronal isoform of NOS (nNOS) in granule cells. Conversely, direct depolarization of cultured neurons with K+ completely downregulated nNOS expression. Suppression of NMDA receptor- and AMPA receptor-mediated spontaneous synaptic signaling in cultured cells resulted in a drastic upregulation of nNOS expression in granule neurons. In contrast, blockade of GABA(A) receptor-mediated intercellular communication did not affect nNOS expression by granule cells. Blocking N-, P-, and Q-type voltage-dependent Ca2+ channels resulted in a graded upregulation of NOS expression, whereas manipulations of the cAMP-dependent signal transduction pathway induced no changes. We conclude that nNOS expression in developing cerebellar granule cells is regulated by excitatory neurotransmission and that calcium is an important signal transduction molecule involved in this regulatory process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 19:00:14