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Titolo:
LEISHMANIA PROMASTIGOTES SELECTIVELY INHIBIT INTERLEUKIN-12 INDUCTIONIN BONE-MARROW-DERIVED MACROPHAGES FROM SUSCEPTIBLE AND RESISTANT MICE
Autore:
CARRERA L; GAZZINELLI RT; BADOLATO R; HIENY S; MULLER W; KUHN R; SACKS DL;
Indirizzi:
NIAID,PARASIT DIS LAB,NIH,BLDG 4,ROOM 126 BETHESDA MD 20892 NIAID,PARASIT DIS LAB,NIH BETHESDA MD 20892 NCI,DIV CANC TREATMENT,PROGRAM RESOURCES INC DYNCORP,BIOL CARCINOGENESIS & DEV PROGRAM FREDERICK MD 21702 UNIV COLOGNE,INST GENET D-50923 COLOGNE GERMANY
Titolo Testata:
The Journal of experimental medicine
fascicolo: 2, volume: 183, anno: 1996,
pagine: 515 - 526
SICI:
0022-1007(1996)183:2<515:LPSIII>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA-PRODUCTION; NATURAL-KILLER-CELLS; PROTEIN-KINASE-C; NECROSIS-FACTOR-ALPHA; GROWTH-FACTOR-BETA; CD4+ T-CELLS; IFN-GAMMA; MURINE LEISHMANIASIS; SIGNAL TRANSDUCTION; CYTOKINE PRODUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
L. Carrera et al., "LEISHMANIA PROMASTIGOTES SELECTIVELY INHIBIT INTERLEUKIN-12 INDUCTIONIN BONE-MARROW-DERIVED MACROPHAGES FROM SUSCEPTIBLE AND RESISTANT MICE", The Journal of experimental medicine, 183(2), 1996, pp. 515-526

Abstract

Leishmania major promastigotes were found to avoid activation of mouse bone marrow-derived macrophages (BMMo) in vitro for production of cytokines that are typically induced during infection with other intracellular pathogens. Coexposure of BMMo to the parasite and other microbial stimuli resulted in complete inhibition of interleukin (IL) 12 (p40) mRNA induction and IL-12 release. In contrast, mRNA and protein levels for IL-1 alpha, IL-1 beta, tumor necrosis factor (TNF) alpha, and inducible NO synthase (iNOS) were only partially reduced, and signals for IL-10 and monocyte chemoattractant protein (MCP-1/JE) were enhanced. The parasite could provide a detectable trigger for TNF-alpha and iNOS in BMMo primed with interferon (IFN) gamma, but still failed to induce IL-12. Thus IL-12 induction is selectively impaired after infection, whereas activation pathways for other monokine responses remain relatively intact. Selective and complete inhibition of IL-12(p40) induction was observed using BMMo from either genetically susceptible or resistant mouse strains, as well as IL-10 knockout mice, and was obtainedusing promastigotes from cutaneous, visceral, and lipophosphoglycan-deficient strains of Leishmania. The impaired production of the major physiologic inducer of IFN-gamma is suggested to underlie the relatively prolonged interval of parasite intracellular survival and replication that is typically associate with leishmanial infections, including those producing self-limiting disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 01:03:00