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Titolo:
GAP-JUNCTIONS PLAY A ROLE IN THE BYSTANDER EFFECT OF THE HERPES-SIMPLEX VIRUS THYMIDINE KINASE GANCICLOVIR SYSTEM IN-VITRO
Autore:
ELSHAMI AA; SAAVEDRA A; ZHANG H; KUCHARCZUK JC; SPRAY DC; FISHMAN GI; AMIN KM; KAISER LR; ALBELDA SM;
Indirizzi:
HOSP UNIV PENN,THORAC ONCOL RES LAB,809 MALONEY BLDG,3600 SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT MED,DIV PULM CRIT CARE PHILADELPHIA PA 00000 UNIV PENN,MED CTR,DEPT SURG,THORAC SURG SECT PHILADELPHIA PA 00000 ALBERT EINSTEIN COLL MED,DEPT NEUROSCI BRONX NY 00000 ALBERT EINSTEIN COLL MED,DEPT MED BRONX NY 00000 ALBERT EINSTEIN COLL MED,DEPT MED & MOLEC GENET BRONX NY 00000
Titolo Testata:
Gene therapy
fascicolo: 1, volume: 3, anno: 1996,
pagine: 85 - 92
SICI:
0969-7128(1996)3:1<85:GPARIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-TRANSFER; BRAIN-TUMORS; CELLS; COMMUNICATION; SPECIFICITY; EXPRESSION; INVIVO; GROWTH;
Keywords:
BYSTANDER EFFECT; GAP JUNCTIONS; THYMIDINE KINASE; GANCICLOVIR; GENE THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Elshami et al., "GAP-JUNCTIONS PLAY A ROLE IN THE BYSTANDER EFFECT OF THE HERPES-SIMPLEX VIRUS THYMIDINE KINASE GANCICLOVIR SYSTEM IN-VITRO", Gene therapy, 3(1), 1996, pp. 85-92

Abstract

Tumor cells transduced with the herpes simplex virus thymidine kinase(HSVtk) gene are sensitive to the anti-viral drug ganciclovir (GCV). However, nearby untransduced tumor cells are also efficiently killed. The mechanism of this 'bystander effect' was studied by comparing pairs of tumor cell lines transfected with connexin genes that differed only in their degree of gap junctional communication. More efficient cell killing was uniformly seen in connexin transfectants compared with the less coupled cell lines. These results provide direct evidence thatgap junctional communication plays an important role in mediating thebystander effect of the HSVtk/GCV system in vitro and have important prognostic and therapeutic implications for future gene therapy trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:37:00