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Titolo:
A NOVEL CYTOPLASMIC DUAL-SPECIFICITY PROTEIN-TYROSINE-PHOSPHATASE IMPLICATED IN MUSCLE AND NEURONAL DIFFERENTIATION
Autore:
MOUREY RJ; VEGA QC; CAMPBELL JS; WENDEROTH MP; HAUSCHKA SD; KREBS EG; DIXON JE;
Indirizzi:
UNIV MICHIGAN,DEPT BIOL CHEM ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT BIOL CHEM ANN ARBOR MI 48109 UNIV WASHINGTON,DEPT PHARMACOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOCHEM SEATTLE WA 98195
Titolo Testata:
The Journal of biological chemistry
fascicolo: 7, volume: 271, anno: 1996,
pagine: 3795 - 3802
SICI:
0021-9258(1996)271:7<3795:ANCDPI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; MAP KINASE; VACCINIA VIRUS; ACTIVATION; EXPRESSION; CASCADE; CLONING; ENCODES; CULTURE; 3CH134;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Mourey et al., "A NOVEL CYTOPLASMIC DUAL-SPECIFICITY PROTEIN-TYROSINE-PHOSPHATASE IMPLICATED IN MUSCLE AND NEURONAL DIFFERENTIATION", The Journal of biological chemistry, 271(7), 1996, pp. 3795-3802

Abstract

Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). In addition to hydrolyzing phosphotyrosine, dsPTPs can hydrolyze phosphoserine/threonine-containing substrates and have been shown to dephosphorylate activated MAPK. We have identified a novel dsPTP, rVH6, from rat hippocampus. rVH6 containsthe conserved dsPTP active site sequence, VXVHCX(2)GX(2)RSX(5)AY(L/I)M, and exhibits phosphatase activity against activated MAPK. In PC12 cells, rVH6 mRNA is induced during nerve growth factor-mediated differentiation but not during insulin or epidermal growth factor mitogenic stimulation. In MM14 muscle cells, rVH6 mRNA is highly expressed in proliferating cells and declines rapidly during differentiation. rVH6 expression correlates with the inability of fibroblast growth factor to stimulate MAPK activity in proliferating but not in differentiating MM14 cells. rVH6 protein localizes to the cytoplasm and is the first dsPTP to be localized outside the nucleus. This novel subcellular localization may expose rVH6 to potential substrates that differ from nuclear dsPTPs substrates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:18:27