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Titolo:
ACUTE BLOOD-PRESSURE ELEVATIONS WITH CAFFEINE IN MEN WITH BORDERLINE SYSTEMIC HYPERTENSION
Autore:
PINCOMB GA; LOVALLO WR; MCKEY BS; SUNG BH; PASSEY RB; EVERSON SA; WILSON MF;
Indirizzi:
UNIV OKLAHOMA,HLTH SCI CTR,VET AFFAIRS MED CTR,BEHAV SCI LABS 151A,921 NE 13TH ST OKLAHOMA CITY OK 73104 UNIV OKLAHOMA,HLTH SCI CTR,VET AFFAIRS MED CTR,MED RES SERV OKLAHOMA CITY OK 73104 UNIV OKLAHOMA,HLTH SCI CTR,DEPT PSYCHIAT & BEHAV SCI OKLAHOMA CITY OK73190 UNIV OKLAHOMA,HLTH SCI CTR,DEPT MED OKLAHOMA CITY OK 73104 UNIV OKLAHOMA,HLTH SCI CTR,DEPT PATHOL OKLAHOMA CITY OK 73104 UNIV OKLAHOMA,HLTH SCI CTR,COLL PHARM OKLAHOMA CITY OK 73190
Titolo Testata:
The American journal of cardiology
fascicolo: 4, volume: 77, anno: 1996,
pagine: 270 - 274
SICI:
0002-9149(1996)77:4<270:ABEWCI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPEDANCE CARDIOGRAPHY; COFFEE DRINKERS; REGULAR COFFEE; YOUNG MEN; EXERCISE; STRESS; REST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Pincomb et al., "ACUTE BLOOD-PRESSURE ELEVATIONS WITH CAFFEINE IN MEN WITH BORDERLINE SYSTEMIC HYPERTENSION", The American journal of cardiology, 77(4), 1996, pp. 270-274

Abstract

Whether the vasoconstrictive actions of caffeine are enhanced in hypertensive persons has not been demonstrated, Thus caffeine 13.3 mg/kg) versus placebo was tested in 48 healthy men (aged 20 to 35 years) selected after screening on 2 separate occasions. Borderline hypertensive men (n = 24) were selected with screening systolic blood pressure (BP)of 140 to 160 mm Ha and/or diastolic BP 90 to 99 mm Hg. Low-risk controls In = 24) reported no parental history of hypertension and had screening BP <130/85 mm Hg. Participants were then tested on 2 occasions after 12-hour abstinence from caffeine in each of 2 protocols; this required a total of 4 laboratory visits. Caffeine-induced changes in diastolic BP were 2 to 3 times larger in borderline subjects than in controls (+8.4 vs +3.8 mm Hg, p <0.0001), and were attributable to larger changes in impedance-derived measures of systemic vascular resistance (+135 vs +45 dynes . s . cm(-5), p <0.004). These findings were consistent and reached significance in both protocols. The percentage of borderline subjects in whom diastolic BP changes exceeded the median control response was 96%, Consequently whereas all participants exhibited normotensive levels during the resting predrug baseline, 33% of borderline subjects achieved hypertensive BP levels after caffeine ingestion, Thus, in borderline hypertensive men, exaggerated responses to caffeine were: selective for diastolic BP, consistent with greater vasoconstriction, replicated in 2 protocols, and representative of nearly all borderline hypertensives, We suspect that the potential far caffeine to stabilize high resistance states in susceptible persons suggests that its use may facilitate their disease progression, as well as hinder accurate diagnosis and treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 12:03:52