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Titolo:
COMPARISON OF 4 CYTOKINE REGIMENS FOR MOBILIZATION OF PERIPHERAL-BLOOD STEM-CELLS - IL-3 ALONE AND COMBINED WITH GM-CSF OR G-CSF
Autore:
ROSENFELD CS; BOLWELL B; LEFEVER A; TAYLOR R; LIST A; FAY J; COLLINS R; ANDREWS F; PALLANSCH P; SCHUSTER MW; RESTA D; LEVITT D; NEMUNAITIS J;
Indirizzi:
STEM CELL TRANSPLANT & RES PROGRAM,7777 FOREST LANE DALLAS TX 75230 TEXAS ONCOL PROFESS ASSOC DALLAS TX 00000 CLEVELAND CLIN CLEVELAND OH 44106 ST LUKES HOSP MILWAUKEE WI 00000 ARIZONA CANC CTR TUCSON AZ 00000 WESTERN PENN CANC INST PITTSBURGH PA 00000 N SHORE UNIV MANHASSET NY 00000 SANDOZ PHARMACEUT CORP E HANOVER NJ 00000
Titolo Testata:
Bone marrow transplantation
fascicolo: 2, volume: 17, anno: 1996,
pagine: 179 - 183
SICI:
0268-3369(1996)17:2<179:CO4CRF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; RECOMBINANT HUMAN INTERLEUKIN-3; BONE-MARROW TRANSPLANTATION; HIGH-DOSE CYCLOPHOSPHAMIDE; PROGENITOR CELLS; HEMATOPOIETIC PROGENITOR; PLATELET RECOVERY; GRANULOCYTE; CHEMOTHERAPY; INVIVO;
Keywords:
INTERLEUKIN-3; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; TRANSPLANTATION; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BREAST NEOPLASMS; LYMPHOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.S. Rosenfeld et al., "COMPARISON OF 4 CYTOKINE REGIMENS FOR MOBILIZATION OF PERIPHERAL-BLOOD STEM-CELLS - IL-3 ALONE AND COMBINED WITH GM-CSF OR G-CSF", Bone marrow transplantation, 17(2), 1996, pp. 179-183

Abstract

Improved methods for mobilization may reduce the number of aphereses required to collect adequate numbers of peripheral blood stem cells (PBSC) and hasten engraftment following high-dose therapy. Mobilization with cytokines alone enables engraftment after myeloablative therapy, The optimal cytokine regimen for mobilization has not been established, The study evaluated the effects of four interleukin-3-containing cytokine regimens administered during steady state hematopoiesis on PBSC mobilization in 30 patients with breast cancer or lymphoid malignancies, These regimens included IL-3 alone (Arm 1), sequential IL-3 --> G-CSF (Arm 2), sequential IL-3 --> GM-CSF (Arm 3) and combined IL-3 + G-CSF (Arm 4). Consecutive days of apheresis were performed until a target of 4-6 x 10(8) mononuclear cells/kg were collected, All patients received intravenous GM-CSF after PBSC infusion. Median days to an ANC greater than or equal to 500/mu l in Arm 3 (22 days) was significantly slower than for patients in Arm 2 (13 days) but not significantly different from patients in Arm 1 or Arm 4, There was no significant difference in platelet engraftment or days of hospitalization between the study arms, Addition of GM-CSF to IL-3-containing mobilization regimens results in collection of PBSC that lead to delayed engraftment, Furtherdevelopment of Arms 1, 2, and 4 appear warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:35:04