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Titolo:
REGULATION OF DOPAMINE RELEASE AND METABOLISM IN RAT STRIATUM IN-VIVO- EFFECTS OF DOPAMINE-RECEPTOR ANTAGONISTS
Autore:
RAYEVSKY KS; GAINETDINOV RR; GREKHOVA TV; SOTNIKOVA TD;
Indirizzi:
RUSSIAN ACAD MED SCI,INST PHARMACOL,LAB NEUROCHEM PHARMACOL,BALTIYSKAYA STR 8 MOSCOW 125315 RUSSIA
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 8, volume: 19, anno: 1995,
pagine: 1285 - 1303
SICI:
0278-5846(1995)19:8<1285:RODRAM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; FREELY MOVING RATS; NUCLEUS-ACCUMBENS; FOS EXPRESSION; BRAIN DIALYSIS; AWAKE RATS; C-FOS; NEUROLEPTICS; INVIVO; CLOZAPINE;
Keywords:
D2 DOPAMINE RECEPTOR; D3 DOPAMINE RECEPTOR; DOPAMINE METABOLISM; DOPAMINE RELEASE; MICRODIALYSIS; NEUROLEPTICS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Rayevsky et al., "REGULATION OF DOPAMINE RELEASE AND METABOLISM IN RAT STRIATUM IN-VIVO- EFFECTS OF DOPAMINE-RECEPTOR ANTAGONISTS", Progress in neuro-psychopharmacology & biological psychiatry, 19(8), 1995, pp. 1285-1303

Abstract

1. The acute effects of some of typical and atypical antipsychotic drugs on the dopamine release and metabolism in the dorsal striatum of freely moving rats were studied using transcerebral microdialysis technique. 2. Classical neuroleptic drugs haloperidol(0.05, 0.1 and 0.2 mg/kg), thioproperazine (0.1, 0.2 and 0.4 mg/kg) and spiperone (0.02, 0.04 and 0.07 mg/kg) administered i.p. induced pronounced elevation of extracellular level of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) up to 250-300 % to basal level while producing less increase in that of dopamine (DA) (up to 150-170 %). 3. Atypical neuroleptics clozapine and thioridazine (both 2, 5 and 20 mg/kg) increased striatal DA release and DOPAC level approximately at the same degree (maximally up to 200% and 160%, respectively). 4. Dopamine D3 receptor and autoreceptor preferring antagonists (+)-UH232 and (+)-AJ76 (both 4, 7 and 14 mg/kg) more potently increased DA release in comparison with DOPAC dialysate level ( (+)-AJ76 elevated DA level maximally up to 330 %, DOPAC - up to 250 %). 5. The features of typical and atypical neuroleptics in preferential action on DA release or DOPAC output were observed in all. doses of the drugs studied. 6. The ability of the drugs to affect preferentially DA release or DOPAC extracellular level in rat striatum correlates to their relative affinities at D3 and D2 DA receptors. 7. It is concluded that typical and atypical antipsychotic drugs might be clearly distinguished on the basis of their ability to affect preferentially DA synthesis/metabolism or release in rat dorsal striatum in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:56:40