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Titolo:
BEHAVIOR OF RAPHE CELLS PROJECTING TO THE DORSOMEDIAL MEDULLA DURING CARBACHOL-INDUCED ATONIA IN THE CAT
Autore:
WOCH G; DAVIES RO; PACK AI; KUBIN L;
Indirizzi:
UNIV PENN,SCH VET MED,DEPT ANIM BIOL,3600 SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,SCH VET MED,DEPT ANIM BIOL PHILADELPHIA PA 19104 UNIV PENN,SCH MED,CTR SLEEP & RESP NEUROBIOL PHILADELPHIA PA 19104
Titolo Testata:
Journal of physiology
fascicolo: 3, volume: 490, anno: 1996,
pagine: 745 - 758
SICI:
0022-3751(1996)490:3<745:BORCPT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN-CONTAINING NEURONS; NUCLEUS TRACTUS SOLITARII; FREELY MOVING CATS; SLEEP-WAKING CYCLE; DECEREBRATE CAT; BRAIN-STEM; HYPOGLOSSAL MOTONEURONS; PARADOXICAL SLEEP; TRIGEMINAL MOTOR; REM-SLEEP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
G. Woch et al., "BEHAVIOR OF RAPHE CELLS PROJECTING TO THE DORSOMEDIAL MEDULLA DURING CARBACHOL-INDUCED ATONIA IN THE CAT", Journal of physiology, 490(3), 1996, pp. 745-758

Abstract

1. The activity of most brainstem serotonergic cells is suppressed during sleep, particularly the rapid eye movement (REM) phase. Thus, they may play a major role in state-dependent changes in CNS functioning. Our main goal was to search for medullary raphe cells having axonal branches in the region of the hypoglossal (XII) motor nucleus and assess their behaviour during the atonia produced by microinjections of a cholinergic agonist, carbachol, into the dorsal pontine tegmentum. In chronic animals, such microinjections evoke a desynchronized sleep-likestate similar to natural REM sleep; in decerebrate animals, they produce eye movements and a motor suppression similar to the postural atonia of REM sleep. 2. In decerebrate, paralysed, vagotomized and artificially ventilated cats, we recorded extracellularly from medullary raphe cells antidromically activated from the XII nucleus region. Forty-five cells recorded in the raphe obscurus and pallidus nuclei were antidromically activated with latencies characteristic of non-myelinated fibres (4.4-42.0 ms). For thirty-three of the forty-five cells, we foundone or more axonal branches within or just below the XII nucleus. Theremaining twelve cells, in addition to the XII nucleus, had axonal ramifications in the medial nucleus of the solitary tract (NTS) and/or the dorsal motor nucleus of the vagus (DMV). 3. A subset of fourteen spontaneously active cells with identified axonal projections were held long enough to be recorded during the carbachol-induced atonia, and eight of these also during the subsequent recovery and a systemic administration of the serotonergic 1A receptor agonist (+/-)8-hydroxy-2-(di-N-propylamino)tetrealin hydrobromide (8-OH-DPAT). All but one mere suppressed during the atonia in parallel to the suppression of XII, phrenic and postural nerve activities (firing rate, 1.3 +/- 0.7 Hz before and 0.1 +/- 0.2 Hz after carbachol (means +/- S.D.)). Following the recovery from the atonia, the firing rates of the eight cells increased to the pre-carbachol level (1.6 +/- 1.0 Hz). Subsequently, all were silenced by 8-OH-DPAT. 4. These cells fulfil most physiological criteria for serotonergic cells and have the potential to modulate, in a state-dependent manner, activities in the motor XII nucleus, visceral sensory NTS, and DMV. The decrements in serotonergic neuronal activity that occur during the carbachol-induced atonia suggest that a similar withdrawal of serotonergic input may occur during REM sleep and contribute to the characteristic reductions in upper airway motor tone.

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Documento generato il 30/09/20 alle ore 01:26:31