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Titolo:
INTRON MOBILITY IN PHAGE-T4 OCCURS IN THE CONTEXT OF RECOMBINATION-DEPENDENT DNA-REPLICATION BY WAY OF MULTIPLE PATHWAYS
Autore:
MUELLER JE; CLYMAN T; HUANG YJ; PARKER MM; BELFORT M;
Indirizzi:
NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,MOLEC GENET PROGRAMALBANY NY 12201 NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,MOLEC GENET PROGRAMALBANY NY 12201 SUNY ALBANY,SCH PUBL HLTH ALBANY NY 12201
Titolo Testata:
Genes & development
fascicolo: 3, volume: 10, anno: 1996,
pagine: 351 - 364
SICI:
0890-9369(1996)10:3<351:IMIPOI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFECTING GENETIC-RECOMBINATION; THYMIDYLATE SYNTHASE GENE; OPEN READING FRAMES; BREAK REPAIR MODEL; ENDONUCLEASE-VII; TD-INTRON; BACTERIOPHAGE-T4; PROTEINS; SYSTEM; MUTATIONS;
Keywords:
GROUP I INTRON; INTRON HOMING; RECOMBINATION-DEPENDENT REPLICATION; DOUBLE-STRAND-BREAK REPAIR; SYNTHESIS-DEPENDENT STRAND ANNEALING PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Mueller et al., "INTRON MOBILITY IN PHAGE-T4 OCCURS IN THE CONTEXT OF RECOMBINATION-DEPENDENT DNA-REPLICATION BY WAY OF MULTIPLE PATHWAYS", Genes & development, 10(3), 1996, pp. 351-364

Abstract

Numerous group I introns in both prokaryotes and eukaryotes behave asmobile genetic elements. The functional requirements for intron mobility were determined in the T4 phage system using an in vivo assay to measure intron homing with wild-type and mutant derivatives. Thus, it was demonstrated that intron mobility occurs in the context of phage recombination-dependent replication, a pathway that uses overlapping subsets of replication and recombination functions. The functional requirements for intron homing and the nature of recombinant products are only partially consistent with the accepted double-strand-break repair (DSBR) model for intron inheritance, and implicate additional homing pathways. Whereas ambiguities in resolvase requirements and underrepresentation of crossover recombination products are difficult to rationalize strictly by DSBR, these properties are most readily consistent witha synthesis-dependent strand annealing (SDSA) pathway. These pathwaysshare common features in the strand invasion steps, but differ in subsequent repair synthesis and resolution steps, influencing the geneticconsequences of the intron transfer event.

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Documento generato il 27/11/20 alle ore 12:32:26