Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF A NONPEPTIDE ANGIOTENSIN RECEPTOR ANTAGONIST ON WATER-INTAKE CAUSED BY CENTRALLY ADMINISTERED CARBACHOL IN THE RAT
Autore:
REIS LC; SAAD WA; CAMARGO LAA; RENZI A; MENANI JV;
Indirizzi:
UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,RUA HUMAITA 1680,CAIXA POSTAL 331 BR-14801903 ARARAQUARA SP BRAZIL UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 2, volume: 29, anno: 1996,
pagine: 245 - 247
SICI:
0100-879X(1996)29:2<245:EOANAR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
II BINDING-SITES; CONVERTING ENZYME;
Keywords:
WATER INTAKE; ANGIOTENSIN 11; CARBACHOL; DUP-753; ANGIOTENSIN RECEPTOR ANTAGONIST; AT1 RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
L.C. Reis et al., "EFFECT OF A NONPEPTIDE ANGIOTENSIN RECEPTOR ANTAGONIST ON WATER-INTAKE CAUSED BY CENTRALLY ADMINISTERED CARBACHOL IN THE RAT", Brazilian journal of medical and biological research, 29(2), 1996, pp. 245-247

Abstract

Angiotensin II (ANG II) administered centrally produces drinking by acting on subtype 1 ANG II (AT1) receptors, Carbachol, a cholinergic receptor agonist, also induces drinking behavior by a central action. Inthe present study we determined whether the response to carbachol also involves AT1 receptors. Male Holtzman rats (250-300 g) with stainless steel cannula implanted into the lateral ventricle (LV) were used. Water intake after injection of 0.15 M NaCl (1.0 mu l) into the LV was 0.2 +/- 0.01 ml/h (N = 8). The AT1 receptor antagonist DUP-753 (50 nmol/mu l) injected into the LV reduced water intake induced by ANG II (10 nmol/mu l) from 9.2 +/- 1.4 to 0.4 +/- 0.1 ml/h (N = 8), and water intake induced by carbachol (2 nmol/mu l) from 9.8 +/- 1.4 ml/h to 3.7 /- 0.8 ml/h (N = 8), These results suggest that AT1 receptors play a role in the drinking behavior observed after central cholinergic stimulation in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:30:08