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Titolo:
THE ROLE OF HEPATOBILIARY SCINTIGRAPHY IN CYSTIC-FIBROSIS
Autore:
OCONNOR PJ; SOUTHERN KW; BOWLER IM; IRVING HC; ROBINSON PJ; LITTLEWOOD JM;
Indirizzi:
ST JAMES UNIV HOSP,DEPT DIAGNOST RADIOL LEEDS LS9 7TF W YORKSHIRE ENGLAND ST JAMES UNIV HOSP,REG PAEDIAT CYST FIBROSIS UNIT LEEDS LS9 7TF W YORKSHIRE ENGLAND
Titolo Testata:
Hepatology
fascicolo: 2, volume: 23, anno: 1996,
pagine: 281 - 287
SICI:
0270-9139(1996)23:2<281:TROHSI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
URSODEOXYCHOLIC ACID THERAPY; BILIARY LIPID-COMPOSITION; DUCT EPITHELIAL-CELLS; LIVER-DISEASE; CIRRHOSIS; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Oconnor et al., "THE ROLE OF HEPATOBILIARY SCINTIGRAPHY IN CYSTIC-FIBROSIS", Hepatology, 23(2), 1996, pp. 281-287

Abstract

This was a prospective open study that examined the quantitative and qualitative analysis of hepatobiliary scintigraphy (DISIDA) in detecting liver involvement in cystic fibrosis (CF). Forty-four adult and pediatric patients (median age, 12.1 years; range, 1.1-36.3 years) were divided into three groups: group 1, no evidence of liver involvement (n= 8); group 2, biochemical evidence of liver involvement on two or more occasions (n = 26); and group 3, clinical evidence of Liver disease(n = 10), In groups 1 and 2, the most common qualitative scintigraphic finding was focal intrahepatic retention of tracer (26/34 patients, 12 of whom had normal findings on ultrasonography). This finding corresponds to focal cholestasis and may warrant treatment with the choleretic agent ursodeoxycholic acid (UDCA), In the group 3 patients, the abnormal qualitative scintigraphic appearances (heterogeneous uptake of tracer and nodular liver outline) added little to the findings on ultrasonography; however, these patients had a prolonged mean hepatic clearance time compared with those in groups 1 and 2 (one-way ANOVA; P < .015). It is proposed that scintigraphy with DISIDA has a role in the detection of early Liver involvement in cystic fibrosis.

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Documento generato il 30/11/20 alle ore 06:12:06