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Titolo:
THE ROLE OF FLUMAZENIL IN THE MANAGEMENT OF PATIENTS WITH ACUTE ALTERATION OF MENTAL STATUS IN THE EMERGENCY DEPARTMENT
Autore:
CHERN TL; HU SC; LEE CH; DENG JF;
Indirizzi:
LOTUNG ST MARYS HOSP,EMERGENCY ROOM TAIPEI TAIWAN VET GEN HOSP,DEPT MED,DIV CLIN TOXICOL TAIPEI TAIWAN VET GEN HOSP,DEPT EMERGENCY TAIPEI TAIWAN
Titolo Testata:
Human & experimental toxicology
fascicolo: 1, volume: 13, anno: 1994,
pagine: 45 - 50
SICI:
0960-3271(1994)13:1<45:TROFIT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTENSIVE-CARE UNIT; BENZODIAZEPINE ANTAGONIST; DIAGNOSTIC UTILITY; CLINICAL USE; COMA; INTOXICATIONS; NALOXONE; ANEXATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Chern et al., "THE ROLE OF FLUMAZENIL IN THE MANAGEMENT OF PATIENTS WITH ACUTE ALTERATION OF MENTAL STATUS IN THE EMERGENCY DEPARTMENT", Human & experimental toxicology, 13(1), 1994, pp. 45-50

Abstract

1 There are a few case reports which suggest that flumazenil can be used as a diagnostic tool in coma of unknown aetiology but no large scale studies have proved its efficacy and cost-effectiveness. 2 Fifty five patients with acute alteration of mental status of unknown aetiology were enrolled prospectively during a time period of one year. Flumazenil was injected intravenously in a regimen of 0.3 mg in the first minute followed by alternate 0.2 mg, 0.3 mg doses every minute until a total dose of 1 mg was given or until the patients responded. 3 Patients were divided into two groups based on their response to flumazenil: Group 1, responders and Group 2, non-responders, The hospital stay wasshortened significantly and interventional procedures, such as CT of brain and endotracheal intubation, were rendered unnecessary in several patients in Group 1. The Group 1 patients had a more favourable outcome than that of Group 2. 4 We concluded that flumazenil may serve as a useful tool in diagnosis and management of carefully selected patients with acute alteration of mental status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:46:58