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Titolo:
RENAL EXPRESSION OF A TRANSFORMING GROWTH-FACTOR-ALPHA TRANSGENE ACCELERATES THE PROGRESSION OF INHERITED, SLOWLY PROGRESSIVE POLYCYSTIC KIDNEY-DISEASE IN THE MOUSE
Autore:
GATTONE VH; KUENSTLER KA; LINDEMANN GW; LU XJ; COWLEY BD; RANKIN CA; CALVET JP;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT ANAT & CELL BIOL,3901 RAINBOW BLVD KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,DEPT MED KANSAS CITY KS 66160
Titolo Testata:
The Journal of laboratory and clinical medicine
fascicolo: 2, volume: 127, anno: 1996,
pagine: 214 - 222
SICI:
0022-2143(1996)127:2<214:REOATG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOVERY; MODEL; EGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
V.H. Gattone et al., "RENAL EXPRESSION OF A TRANSFORMING GROWTH-FACTOR-ALPHA TRANSGENE ACCELERATES THE PROGRESSION OF INHERITED, SLOWLY PROGRESSIVE POLYCYSTIC KIDNEY-DISEASE IN THE MOUSE", The Journal of laboratory and clinical medicine, 127(2), 1996, pp. 214-222

Abstract

Polycystic kidney disease (PKD) is a prevalent inherited disease in human beings. The pathogenesis of PKD is as yet unclear. The epidermal growth factor family of proteins has been implicated in PKD based largely on in vitro data. To determine whether these growth factors contribute to the progression of inherited PKD in vivo, we crossed mice witha transgene for human transforming growth factor-alpha (TGF-alpha, a member of the epidermal growth factor [EGF] family) and mice with the pcy gene (which causes a slowly progressive form of PKD very similar to human autosomal dominant PKD). Renal expression of the TGF-alpha transgene In cystic mice (homozygous for the pcy gene) accelerated the development of PKD as shown by an increased kidney weight as a percent of body weight and an increased volume density of renal cysts at 8.5 weeks of age. However, renal expression of the TGF-alpha transgene did not appear to precociously initiate cyst development (at 6.5 weeks), nor did it cause an increase in the final degree of renal enlargement (at 29 weeks). Thus TGF-alpha accelerated the enlargement of cysts once initiated. At 8.5 weeks of age, renal expression of the TGF-alpha mRNAcorrelated positively with the amount of renal enlargement. At all time points studied, cystic kidneys exhibited increased expression of c-myc mRNA as compared with phenotypic normal kidneys, consistent with PKD being a hyperplastic disease of renal tubules. However, the renal expression of c-myc in 8.5 week cystic kidneys, with or without the transgene, did not correlate with the degree of renal enlargement. The results of this study suggest that EGF-like proteins may accelerate the progression of inherited renal cystic disease. However, the final degree of cystic change is dictated by the primary disease process rather than by the continued presence of growth factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:21:18