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Titolo:
OZONE INDUCTION OF CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT (CINC)AND NUCLEAR FACTOR-KAPPA-B IN RAT LUNG - INHIBITION BY CORTICOSTEROIDS
Autore:
HADDAD EB; SALMON M; KOTO H; BARNES PJ; ADCOCK I; CHUNG KF;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI & TECHNOL,NATL HEART & LUNG INST,DEPT THORAC MED,DOVEHOUSE ST LONDON SW3 6LY ENGLAND UNIV LONDON IMPERIAL COLL SCI & TECHNOL,NATL HEART & LUNG INST,DEPT THORAC MED LONDON SW3 6LY ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 379, anno: 1996,
pagine: 265 - 268
SICI:
0014-5793(1996)379:3<265:OIOCNC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR; CHEMOTACTIC FACTOR; POLYMORPHONUCLEAR LEUKOCYTES; INTERLEUKIN-8 FAMILY; EPITHELIOID CELLS; EXPRESSION; ACTIVATION; GRO; INFLAMMATION; FIBROBLASTS;
Keywords:
OZONE; CHEMOKINE; CINC MESSENGER-RNA; LUNG INFLAMMATION; NF-KAPPA-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E.B. Haddad et al., "OZONE INDUCTION OF CYTOKINE-INDUCED NEUTROPHIL CHEMOATTRACTANT (CINC)AND NUCLEAR FACTOR-KAPPA-B IN RAT LUNG - INHIBITION BY CORTICOSTEROIDS", FEBS letters, 379(3), 1996, pp. 265-268

Abstract

We determined in rat lung whether ozone exposure was associated with the expression of the chemokine, cytokine-induced neutrophil chemoattractant (CINC), and of the transcription factor, NF-kappa B. CINC mRNA expression peaked at 2 h after cessation of ozone exposure, and returned to basal levels by 24 h, DNA-binding activity of NF-kappa B showed a marked increase after ozone, maxima at 2 h, Dexamethasone inhibited CINC mRNA and NF-kappa B expression, together with neutrophilic inflammation, Our data supports the concept that ozone leads to NF-kappa B activation which increases CINC mRNA expression, These series of eventscould lead to neutrophilic inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 11:23:49