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Titolo:
SIGNIFICANCE OF CYTOGENETIC FINDINGS FOR THE CLINICAL OUTCOME IN PATIENTS WITH T-CELL LYMPHOMA OF ANGIOIMMUNOBLASTIC LYMPHADENOPATHY TYPE
Autore:
SCHLEGELBERGER B; ZWINGERS T; HOHENADEL K; HENNEBRUNS D; SCHMITZ N; HAFERLACH T; TIRIER C; BARTELS H; SONNEN R; KUSE R; GROTE W;
Indirizzi:
CHRISTIAN ALBRECHTS UNIV KIEL,DEPT HUMAN GENET,SCHWANENWEG 24 D-24105KIEL GERMANY CHRISTIAN ALBRECHTS UNIV KIEL,DEPT SURG D-24105 KIEL GERMANY CHRISTIAN ALBRECHTS UNIV KIEL,DEPT INTERNAL MED 2 D-24105 KIEL GERMANY ESTIMATE GMBH MUNCHEN MUNICH GERMANY EVANGELICAL HOSP ESSEN WERDEN ESSEN GERMANY MUNICIPAL HOSP LUBECK LUBECK GERMANY GEN HOSP ST GEORG HAMBURG GERMANY
Titolo Testata:
Journal of clinical oncology
fascicolo: 2, volume: 14, anno: 1996,
pagine: 593 - 599
SICI:
0732-183X(1996)14:2<593:SOCFFT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-ALPHA; IMMUNOBLASTIC LYMPHADENOPATHY; CHROMOSOMAL-ABNORMALITIES; LYMPHOGRANULOMATOSIS-X; COMPLETE REMISSION; DYSPROTEINEMIA; REARRANGEMENT; GENE; AILD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B. Schlegelberger et al., "SIGNIFICANCE OF CYTOGENETIC FINDINGS FOR THE CLINICAL OUTCOME IN PATIENTS WITH T-CELL LYMPHOMA OF ANGIOIMMUNOBLASTIC LYMPHADENOPATHY TYPE", Journal of clinical oncology, 14(2), 1996, pp. 593-599

Abstract

Purpose: The aim of this study was to evaluate the significance of cytogenetic findings for the clinical outcome of patients with Angioimmunoblastic Lymphadenopathy (AILD)-Type T-cell lymphoma. Materials and Methods: In a retrospective analysis, the cytogenetic findings of 50 patients with AILD-type T-cell lymphoma were correlated with the frequency of spontaneous and therapy-induced remissions and with survival using the statistical methods of Koplan and Meier and the model of Cox for multivariate analysis. Treatment was not uniform because the patients were treated in different hospitals during a period of 8 years and because a standard therapy has not yet been established. Results: The following cytogenetic findings were associated with a significantly lower incidence of therapy-induced remissions and a significantly shortersurvival duration: presence of aberrant metaphases in unstimulated cultures (P =.04 for both parameters); clones with an additional X chromosome (P =.0001 and P =.03, respectively); structural aberrations of the short arm of chromosome 1, preferentially involving 1p31-32 (P < .001 and P =.04, respectively); and complex aberrant clones with more than four aberrations (P =.0003 and P =.005, respectively), Multivariateanalysis showed that these cytogenetic findings had a significant influence on survival, but therapy modalities did not. Only the presence of complex aberrant clones was an independent prognostic factor. Trisomy 3 had no effect on survival, but patients without trisomy 5 (P =.08) tended to live longer. Conclusion: This is the first study that seems to indicate that cytogenetic findings have prognostic significance in AILD-type T-cell lymphoma. These results must be proven in prospective studies of homogeneously treated patients. (C) 1996 by American Society of Clinical Oncology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:54:03