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Titolo:
VALPROIC ACID TREATMENT OF LEARNING DISORDER AND SEVERELY EPILEPTIFORM EEG WITHOUT CLINICAL SEIZURES
Autore:
GORDON K; BAWDEN H; CAMFIELD P; MANN S; ORLIK P;
Indirizzi:
5850 UNIV AVE,BOX 3070 HALIFAX NS B3J 3G9 CANADA DALHOUSIE UNIV,DEPT PEDIAT HALIFAX NS CANADA IWK CHILDRENS HOSP,DEPT PSYCHOL HALIFAX NS CANADA IWK CHILDRENS HOSP,DEPT ELECTROENCEPHALOG HALIFAX NS CANADA
Titolo Testata:
Journal of child neurology
fascicolo: 1, volume: 11, anno: 1996,
pagine: 41 - 43
SICI:
0883-0738(1996)11:1<41:VATOLD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDIVIDUAL PATIENTS; RANDOMIZED TRIALS; SINGLE SUBJECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
K. Gordon et al., "VALPROIC ACID TREATMENT OF LEARNING DISORDER AND SEVERELY EPILEPTIFORM EEG WITHOUT CLINICAL SEIZURES", Journal of child neurology, 11(1), 1996, pp. 41-43

Abstract

Using a single-patient (n = 1) clinical trial, we studied a 7-year-old boy who presented with unsatisfactory progress in school and whose electroencephalogram had very active independent frontal spike discharges. He had not had clinical seizures. The patient was randomized to receive valproic acid, 125 mg twice daily, (four periods) or matching placebo (four periods) over 8 weeks. Primary endpoints were the WechslerIntelligence Scale for Children-Revised Coding subtest and a handwriting sample. Behavior was monitored using teacher's and parent's Conners questionnaires. His score on the Wechsler Intelligence Scale for Children-Revised Coding subtest was significantly improved while he was taking valproic acid (P = .03). His electroencephalogram improved from a pretreatment recording of 28 spike discharges per minute to a normalrecording while on valproic acid. We conclude that in this patient, valproic acid had a cognitive enhancing effect, probably by reducing epileptiform discharges.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:27:13