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Titolo:
BIOLOGICAL EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR IN PATIENTS WITH UNTREATED ACUTE MYELOID-LEUKEMIA
Autore:
BAER MR; BERNSTEIN SH; BRUNETTO VL; HEINONEN K; MROZEK K; SWANN VL; MINDERMAN H; BLOCK AW; PIXLEY LA; CHRISTIANSEN NP; FAY JW; BARCOS M; RUSTUM Y; HERZIG GP; BLOOMFIELD CD;
Indirizzi:
ROSWELL PK CANC INST,DIV MED,ELM & CARLTON ST BUFFALO NY 14263 GRACE CANC DRUG CTR,DEPT HEMATOL ONCOL BUFFALO NY 00000 GRACE CANC DRUG CTR,DEPT BONE MARROW TRANSPLANT BUFFALO NY 00000 GRACE CANC DRUG CTR,CYTOGENET RES LAB,DIV MED BUFFALO NY 00000 ROSWELL PK CANC INST,DEPT PATHOL BUFFALO NY 14263 BAYLOR UNIV,MED CTR,CHARLES SAMMONS CANC CTR DALLAS TX 00000
Titolo Testata:
Blood
fascicolo: 4, volume: 87, anno: 1996,
pagine: 1484 - 1494
SICI:
0006-4971(1996)87:4<1484:BEORHG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOBLASTIC-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; ACUTE NONLYMPHOCYTIC LEUKEMIA; ARA-C; CYTOSINE-ARABINOSIDE; GM-CSF; BONE-MARROW; BLAST CELLS; INTERLEUKIN-3; CHEMOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Baer et al., "BIOLOGICAL EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR IN PATIENTS WITH UNTREATED ACUTE MYELOID-LEUKEMIA", Blood, 87(4), 1996, pp. 1484-1494

Abstract

Hematopoietic growth factors are being administered to patients with acute myeloid leukemia (AML) both to shorten the duration of chemotherapy-induced neutropenia and in an attempt to increase cytotoxicity of cell cycle-specific agents. However, limited information is available concerning the effects of growth factors in AML patients. To examine the in vivo effects of recombinant human granulocyte colony-stimulatingfactor (G-CSF) on AML cells, laboratory studies were performed beforeand after a 72-hour intravenous infusion of G-CSF (10 mu g/kg/d) administered to 28 untreated AML patients. Twenty-seven patients (96%) showed increases in at least one of the following parameters after G-CSF:blood blasts, bone marrow (BM) blasts, leukemia cells in S phase or interphase cells with leukemia-specific markers shown by fluorescence in situ hybridization. The median paired change in absolute blast countwas +2.7 x 10(9)/L (P =.0001) after G-CSF, as compared with 0.0 during the 72 hours before initiation of G-CSF. The median percentage of BMleukemia cells in S phase increased from 6.0% to 10.7% after G-CSF (median change, +5.9%; P =.009). Interphase BM cells with trisomy 8 or monosomy 7 increased in 6 of 6 patients with these abnormalities (P =.02), with a median percent increase of 47%. Blood neutrophil counts also increased during G-CSF (median paired change, +2.8 x 10(9)/L; P <.0001). Trisomy 8 or monosomy 7 was shown by fluorescence in situ hybridization in post-G-CSF blood neutrophils from 4 of 6 patients but was also present in neutrophils before G-CSF. We conclude that the percentage of leukemia cells in S phase increases and that leukemic cell populations undergo expansion during short-term administration of G-CSF in almost all AML patients. (C) 1996 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:08:41